The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

In Nederland bieden ongeveer 130 van de 700 middelbare scholen een tweetalige stroom aan. Toch is er nog maar weinig wetenschappelijk onderzoek naar CLIL (content and language integrated learning). Met haar proefschrift wil Evelyn van Kampen (promovendus bij het ICLON) bijdragen aan een beter begrip…

Achter de schermen werken er veel verschillende mensen mee aan de projecten binnen de Dappere Kleintjes onderzoekslijn. Zie hieronder een overzicht van het onderzoeksteam.

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

Promotor: S.M. Verduyn Lunel

Tijdens het najaarssemester (september-december) biedt het NIMAR een Engelstalige minor die zich richt op de studie van Marokko vanuit sociaalwetenschappelijk en geesteswetenschappelijk perspectief. Het semester onderwijst etnografische onderzoeksvaardigheden in een Marokkaanse omgeving.

Heeft jouw peuter of kleuter last van verlegen of angstig gedrag? Dan kan één van onze projecten binnen het Dappere Kleintjes onderzoeksproject jou misschien helpen. Bezoek de website voor meer informatie.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

Artful Mathematics: The Heritage of M. C. Escher

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Curved single crystals provide variable, but well-defined surface structures.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

To study how planetary systems come into existence we study much younger systems still in formation.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Werkt u met (ouders van) peuters of kleuters met verlegen of angstig gedrag? Dan zijn wij op zoek naar u. Bezoek de website voor meer informatie.

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Promotor: Prof.dr.ir. E. Deprettere

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

Promotores: J.N. Kok, H.J. Hoogeboom

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

SDN (Software-Defined Networking) represents a revolutionary approach to network architecture that enables the dynamic and flexible management of network resources through software-based control. This dissertation introduces the idea of SDN and its southbound protocol OpenFlow, then presents the formal…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.