Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

De Edinburgh Medal 2016 is uitgereikt aan zowel Kevin Govender van de Office of Astronomy for Development (OAD) als de International Astronomical Union (IAU). De prijs is een erkenning voor het wereldwijd bevorderen van onderwijs en technologie door middel van sterrenkunde. Het programma is het geesteskind…

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Machine Learning is becoming a more and more substantial technology for industry.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular disease is the leading cause of death worldwide.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Hoe gaan Chinese taalleraren om met wie ze zijn als leraar als ze in het buitenland werken? Dit proefschrift biedt heldere, praktijkgerichte antwoorden. Het onderzoekt de identiteit van de leraar - het alledaagse antwoord op de vraag 'Wat voor soort leraar ben ik hier?' - terwijl deze wordt beïnvloed…

Dit proefschrift omvat vier deelstudies waarin de ‘pedagogische vakkennis’ (pedagogical content knowledge ofwel PCK) van bètadocenten wordt onderzocht.

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

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Het terugdringen van agressie is in de afgelopen jaren in toenemende mate een maatschappelijke prioriteit geworden. Agressie in de vroege kindertijd vergroot de kans op latere agressieproblemen en antisociaal gedrag.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Docenten in het hoger onderwijs zijn experts in wát zij doceren, maar niet noodzakelijk in hóe zij dit zouden moeten doen. Dit komt omdat zij vaak weinig tot geen training hebben gehad in het lesgeven. Daarnaast zijn zij over het algemeen meer georiënteerd op hun eigen vakgebied dan op hun rol als docent.…

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

To maximise your personal development, we ensure tutorials are small-scale and staff members extremely accessible. In year one, you’ll have an average of 12 contact hours, half of which comprise lectures (in English) and the remainder tutorials (optionally Dutch or English).

In dit onderzoek wordt hersenontwikkeling voor het eerst direct gelinkt aan sekseverschillen en schoolprestatie. De resultaten ontkrachten de mythe dat jongens achterlopen in hersenontwikkeling.

Miriam Cohen verdedigde haar proefschrift genaamd “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” op 28 juni 2017. Ze schreef haar proefschrift onder supervisie van prof.dr. L.J. van den Herik en prof. dr. C. Stahn.

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In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Op 30 september 2021 verdedigde Babette van Hazebroek haar proefschrift 'Understanding delinquent development from childhood into early adulthood in early onset offenders'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.W. de Keijser en prof. dr. A. Popma (VUMC).

Dit proefschrift beschrijft de ontwikkeling van een beoordelingsprocedure voor docenten, toegespitst op beginnende eerstegraads docenten Engels.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Dit proefschrift gaat over de invloed van inductieprogramma’s op het welbevinden en de professionele ontwikkeling van beginnende docenten, en welke specifieke kenmerken van inductieprogramma’s daarvoor belangrijk zijn. Hiernaar is onderzoek gedaan met een interviewstudie en een grootschalige vragenl…

Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis

This problem analysis raises the importance of a two interlinked questions: (1) what are important digital skills in the public sector? and (2) how well do different organizational and individual factors explain differences in skills levels?

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Promotor: Prof.dr. J.N. Kok

Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.

Including modelling as part of software development appears to have various benefits.