To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

We kunnen ons de conceptuele discussie tussen beide begrippen wel voorstellen. Soms komt bij het horen van deze termen een Hollywood beeld naar voren, soms actualiteit of wetenschappelijk onderzoek. Beide fenomenen worden veelal onderscheiden door hun verschil in doel van de organisatie, modus operandi…

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

Er verandert wat in de plannen voor de ontwikkeling van de Humanities Campus. De Universiteit Leiden moet kosten besparen vanwege de financiële uitdagingen bij de Faculteit Geesteswetenschappen en de bezuinigingen in het hoger onderwijs. Dit betekent onder meer dat het Lipsius-gebouw na de sloop in…

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Ontwerpbureau Inbo en JHK Architecten hebben hun definitieve structuurontwerp voor de nieuwe bèta-campus van de Universiteit Leiden gepresenteerd. In samenwerking met een aantal andere adviseurs wordt vanaf september gestart met het voorlopig ontwerp van de eerste bouwfase.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

De Universiteit Leiden heeft voor de realisatie van haar nieuwe bèta-campus een architect geselecteerd. Ontwerpbureau Inbo in Rotterdam en JHK Architecten hebben als team de Europese aanbesteding voor fase 1 van de nieuwbouw voor de Faculteit Wiskunde en Natuurwetenschappen gewonnen.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

In het hoger onderwijs zijn open leermaterialen beschikbaar die iedereen mag gebruiken, maar ze worden niet zo veel gebruikt.

Het onderzoek richt zich op de vraag hoe op gemeentelijk niveau wordt omgegaan met klachten over jeugdhulp in het vrijwillige kader en welke rol (gemeentelijke) Kinderombudsmannen hierin spelen, door middel van kwalitatief onderzoek.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Promotor: Prof.dr. M. Ubbink

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

De Universiteit Leiden en de gemeente Leiden willen een nieuw plan gaan maken om een alternatieve Humanities Campus in de binnenstad te realiseren. Daarmee komt er geen onteigeningsprocedure voor het woningbouwcomplex De Doelen ten behoeve van de bouw van de nieuwe Humanities Campus voor de Faculteit…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

De Universiteit Leiden kan binnen haar beschikbare eigen grond een alternatieve Humanities Campus bouwen op de huidige locatie in de stad. Dit is de conclusie van een haalbaarheidsstudie. Het college van burgemeester en wethouders van de gemeente Leiden schrijft dit in een brief aan de gemeenteraad.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Op donderdag 15 december is Elisavet Alexiadou gepromoveerd op haar proefschrift: ‘The Right to Health. A Human Rights Perspective with a Case Study on Greece'. Promotor was hoogleraar gezondheidsrecht Aart Hendriks.

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.