Op 1 en 2 december 2022 namen Vincent Delhomme en Carina van Os, beiden verbonden aan het Europa Instituut, deel aan de workshop ‘The European Health Union – Setup, challenges and global outlook’. De workshop werd georganiseerd door het Max Planck Institute for Comparative Public Law and International…

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.

Promotor: G.J.B. van Ommen

Promotie

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Workshop, 21-22 June On 21-22 June, Dr. C.V. Weeda (Leiden University) and Marie-Louise Leonard (University Ca’ Foscari Venezia) organize a workshop on Worker's health and material environment in Port Cities. The workshop focuses on interdisciplinary discussion. ReMA-students are given the opportunity…

Promotie

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Hoe worden nachtruimtes verbeeld, geproduceerd, ervaren en verteld door migrantengemeenschappen in Europa? Dit onderzoeksproject onderzoekt deze vraag in acht Europese steden: Aarhus, Amsterdam, Berlijn, Cork, Galway, Lissabon, Londen en Rotterdam.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Antibiotica, bacteriën en resistentie zijn zeer geschikte onderwerpen voor een profielwerkstuk. Hier vind je alvast een aantal handige links.

Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben stoffen ontdekt die ontstekingsprocessen in de hersenen kunnen verminderen. Daarmee is een eerste stap gezet in de ontwikkeling van potentiële geneesmiddelen voor de behandeling van hersenziekten zoals de ziekten van Alzheimer…

Promotie

In 2009-2010 ontstond in het westerse discours het idee van een meer ‘assertief’ China, een opvatting die China krachtig van de hand wijst. Niettemin is, vooral sinds Xi Jinping in 2012 aan de macht kwam, duidelijk dat China zijn lang gehanteerde buitenlandse beleidsdoctrine van ‘een lage profilering…

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?

The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.