Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Promotor: Prof.dr. B.R. Katzy

Promotor: Prof.dr. M. Ubbink

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Ruim 1200 leerlingen uit groep 7 van basisscholen in Leiden en Den Haag kregen op de verjaardag van de universiteit les van een echte professor.

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

Promotor: K.H. Kuijken

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Seagrass is a marine flowering plant with special adaptations to coastal and marine environments, playing a crucial role in providing a wide range of ecosystem services.

Forming at the nodes of the Cosmic Web and growing hierarchically via mass accretion, galaxy clusters are the largest virialized halos in our universe, composed of dark matter (DM; ≥85%), ionized hot plasma in the intracluster medium (ICM; ≥10-15%), and galaxies (≥1-5%).

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotores: G. Persoon, R. Schefold

Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

LUGO breidt de Green Teams uit over de hele universiteit, te beginnen met de Faculteit der Rechtsgeleerdheid, en nu met teams voor de Archeologie Faculteit en de campus in Den Haag.

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

Op 17 november 2021 verdedigde Cyril-Igor Grigorieff het proefschrift 'The Regime for International Air Carrier Liability'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof.dr. V. Correia (University Paris Saclay).

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: T.J. Aartsma, Co-promotor: R.N. Frese

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Didactiek

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia