In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Promotor: Prof.dr. H.J.A. Rottgering

Metal production is not only energy-intensive and a major source of greenhouse gas (GHG) emissions, but is also associated with other impacts affecting human health and ecosystems.

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

In this course, you will learn about sustainability and staying with the environmental boundaries of our planet. You will gain an understanding of the effects of growing affluence and population growth, the key challenges we are facing, and ways to influence your direct environment.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Vandaag, 23 september, wordt Paul Hooykaas, hoogleraar moleculaire genetica in het Instituut Biologie Leiden (IBL), geïnstalleerd als Akademiehoogleraar.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.

Optical cavities are useful tools to enhance the interaction between light and matter, which is important to make good quantum emitters. However, it turns out that the cavities themselves (without any quantum emitters) are already interesting objects to study.

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

De tentoonstelling Beschermde planten in de Hortus botanicus laat het belang van biodiversiteit zien aan de hand van verhalen over beschermde planten. Geert de Snoo, decaan van de faculteit der wiskunde en natuurwetenschappen en hoogleraar Conservation Biology, opende de tentoonstelling op 22 mei 2015,…

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Overzicht van de vacatures bij de afdeling Economie.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Het Stoepplantjes Burgerwetenschapsproject richt zich op het onderzoeken van de planten die groeien rond de huizen, in de wijken en steden van de deelnemers.

Thierry Rohmer ontving de Ernst Award 2009 van het Gesellschaft Deutscher Chemiker (GDCh) voor zijn publicatie in de Proceedings of the National Academy of Science van de VS op de structuur-functie relatie van de photoreceptor fytochroom. De prijs werd in september gepresenteerd op de jaarlijkse vergadering…

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

Dit paper bespreekt de co-evolutie van enkele soorten in de geslachtengroep Phyllantheae en motten van het geslacht Epicephala.

Kunst en vrije tijd, Kunst en vrije tijd

Het Leiden University Green Office heeft goed nieuws: je kunt nu de meest milieuvriendelijke zoekmachine - Ecosia - standaard maken op een openbare LU-computer!

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Promotie

Is het mogelijk om oxytocine reacties bij gezonde personen farmacologisch te conditioneren en de neurale circuits te identificeren die aan deze conditionering ten grondslag liggen?

In september 2023 zijn we begonnen met het transformeren van een onderbenutte buitenruimte in een groenere en meer biodiverse tuin waar alle studenten en medewerkers van de Schouwburgstraat kunnen ontspannen en genieten.

De Oude Sterrewacht van Leiden is de oudste bestaande universitaire sterrenwacht ter wereld. Terwijl studenten van Universiteit Leiden college krijgen in het grootste gedeelte van het gebouw, dienen het bezoekerscentrum in de kelder en de telescopen op het gebouw het brede publiek. Op deze website vindt…

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…