Leidse wetenschappers onderzoeken in hoeverre Aziatische burgers in de praktijk aanspraak kunnen maken op rechten, die ze op papier hebben. Aan de hand van die kennis adviseren ze overheden en NGO's hoe de situatie voor (vooral arme) burgers verbeterd kan worden.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: B. van de Water

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Promotor: B. van de Water

In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Door sterk gewijzigde maatschappelijke ontwikkelingen is voor de verhouding van staat en religie in Nederland de laatste decennia meer publieke belangstelling ontstaan dan ooit kon worden voorzien. Daarnaast is deze belangstelling langzamerhand een vraagstuk geworden die belangrijk is voor zowel de…

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Al twee eeuwen lang wordt er strijd geleverd over studiefinanciering. Hoe zouden geld en kansen verdeeld moeten worden? In hoeverre mag de staat zich daar mee bemoeien? Wie moet voor studiefinanciering betalen, en wie mag ontvangen? Deze vragen raken aan grote politieke en maatschappelijke verschillen…

Tot de Bataafse Revolutie van 1795 kwamen op het Binnenhof regenten in de Staten-Generaal samen namens zeven soevereine provincies om de Republiek te besturen. Twintig jaar later waren de Staten-Generaal (inmiddels verzamelnaam voor de Eerste en Tweede Kamer) enkel nog medewetgever naast koning Willem…

Op donderdag 13 oktober 2022 heeft de afdeling Staats- en bestuursrecht afscheid genomen van Elly van der Tang- van Loenen die jarenlang fungeerde als mastermentor aan de afdeling Staats- en bestuursrecht van de Universiteit Leiden. Na jaren met veel plezier deze functie te hebben uitgeoefend gaat Elly…

Op vrijdag 8 september vond de jaarlijkse kick-off van de master Staats- en bestuursrecht plaats. De nieuwe studenten werden in het Kijkhuis welkom geheten door Michiel Tjepkema. Vervolgens gaf Sebastiaan Renkema een presentatie over de activiteiten van de studievereniging Res Publica. De mastercoördinator…

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.