This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Het verhaal van Rosalin Kuiper kent vele vertakkingen, en ze komen allemaal uit op zee. Als studente Psychologie koos Rosalin voor een leven als profzeiler.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

Leids alumnus Wil Stutterheim en biologiestudent Wouter Bruins zijn met In Ovo genomineerd voor de Herman Wijffels Innovatieprijs. Met uw stem maken ze kans op de publieksprijs.

People in motion. Dat is het thema van het festival Voice4Thought dat van 21 tot 25 september in Leiden plaatsvindt. Debat, zang, kunst, workshops, een scholierenconferentie. Alles draait om de ontmoeting.

Hoe ziet studeren aan de Universiteit Leiden eruit in het jaar 2075? Tien verrassende, kunstzinnige toekomstvisies maken kans om werkelijkheid te worden. Nu is het aan jou: stem op jouw favoriet!

Het tijdschrift New Scientist selecteerde twee jonge Leidse wetenschappers voor zijn Top 25 van jong talent in Nederland en Vlaanderen: historicus Karwan Fatah-Black en neuropsycholoog Mariska Kret. Wie komt op één? Stem op een van hen.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Ze willen allebei graag jongerenvertegenwoordiger van de Verenigde Naties worden. Aoife Fleming, student International Studies, wil de stem van jongeren laten horen over Duurzame Ontwikkeling, Tugba Kilinc wil de jongerenspreekbuis zijn over Mensenrechten en Veiligheid. Stem nu!

In het kader van de Honours Course ‘Crises in Biology’ die plaatsvond van 19 augustus t/m 2 september 2012 in Normandië, bezochten studenten vele geologische interessante locaties. Een van deze bijzondere plekken was de kust van Arromanches. Hier bemachtigden zij een enorm grote ammoniet die ze dinsdag…

Promotor: A. Kros

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Wat wordt het erfgoedstuk van 2016? Die vraag mag u beantwoorden in de ‘Stuk van het jaar’-verkiezing. Erfgoed Leiden en Omstreken heeft een bijzondere inzending ingestuurd: de identiteitskaart van Einstein.

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.