This thesis introduces the concept of

Celebrating 20 years of environmental research in Cagayan Valley and Sierra Madre

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

De Sustainable Development Goals en curriculumontwerp

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Wij bestuderen de dagelijkse praktijk van individuen, groepen en gemeenschappen - zowel in Nederland als wereldwijd - om ze te plaatsen binnen de complexe processen van sociale en globale ontwikkeling. In Leiden zijn we gespecialiseerd in de gevolgen van globalisering op het gebied van milieu, sociale…

De programmagroep Opvoeding en Ontwikkeling is verantwoordelijk voor onderwijs op zowel bachelor- als masterniveau, met speciale aandacht voor opvoeding en ontwikkeling.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Video games have emerged as one of the most interesting media of the turn of the century. The peculiar characteristic of video games is the biunivocal interaction between the computer and the human player.

Hoe kan ‘Big Data’ worden ingezet bij ontwikkelings- en humanitaire hulp en wat zijn de risico’s daarvan? De Universiteit Leiden en United Nation’s Global Pulse organiseren hierover op 23 oktober in Den Haag een internationale expert meeting.

Leiden University’s Advanced Studies in Public International Law offers two specialisations: International Criminal Law and Peace, Justice, and Development.

De universiteit streeft ernaar dat alle studenten in hun opleiding kennismaken met duurzaamheidsthema’s en -vraagstukken, die zoveel mogelijk aansluiten bij de inhoud van hun opleiding.

Afrika heeft een bevolking van 1,5 miljard mensen. In 2050 zal dit aantal naar verwachting stijgen tot 2,5 miljard. De impact van het continent op de wereldeconomie en samenlevingen, maar ook op het milieu, zal daardoor enorm toenemen.

De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.

De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.

De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.

De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.

De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.

De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.

De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.

Binnen de masteropleiding Education and Child Studies kun je verschillende typen stages lopen.

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Learning about My meaningful Way through life and profession.

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs is verantwoordelijk voor onderwijs op het gebied van leerproblemen binnen de bachelor- en masteropleidingen van het Instituut Pedagogische Wetenschappen.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Promotor: Prof.dr. M. Danhof