Er zijn in Nederland ongeveer 300.000 mensen die regelmatig bloed geven. Vrouwen kunnen tot drie keer per jaar bloed geven en mannen tot vijf keer, wat neerkomt op ongeveer een miljoen bloeddonaties per jaar. Patiënten die dit donorbloed krijgen, verkeren al in een kwetsbare positie. Daarom is kwaliteitsbewaking…

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

In het hoger onderwijs zijn open leermaterialen beschikbaar die iedereen mag gebruiken, maar ze worden niet zo veel gebruikt.

Het onderzoek richt zich op de vraag hoe op gemeentelijk niveau wordt omgegaan met klachten over jeugdhulp in het vrijwillige kader en welke rol (gemeentelijke) Kinderombudsmannen hierin spelen, door middel van kwalitatief onderzoek.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Hoewel de Algemene Verordening Gegevensbescherming (AVG) vanaf mei 2018 de bescherming van persoonsgegevens in de hele EU harmoniseert, resulteren de open normen ervan in combinatie met culturele verschillen tussen landen in verschillen in de praktische implementatie, interpretatie en handhaving van…

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Promotor: Prof.dr. M. Ubbink

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Onderzoeken hoe gegevens afkomstig van draagbare technologieën kunnen worden gebruikt om effectieve gedragsveranderingen te identificeren die hopelijk zullen leiden tot gezondheidsverbeteringen.

Op donderdag 15 december is Elisavet Alexiadou gepromoveerd op haar proefschrift: ‘The Right to Health. A Human Rights Perspective with a Case Study on Greece'. Promotor was hoogleraar gezondheidsrecht Aart Hendriks.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Athletes always strive for the top. How can data scientists assist them in improving their performance? During the seminar Data Science and Sports, the possibilities and challenges of collaboration between these two worlds were discussed.