This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Wij voeren multidisciplinair onderzoek uit op het niveau van moleculen, cellen en organismen binnen de dierkunde. Ons doel is om fundamentele kennis te vergroten over gezondheid en ziekte.

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

De missie van het Plant Sciences onderzoeksprogramma is om bij te dragen aan de duurzame productie van gewassen van hoge kwaliteit, bloemen en hoogwaardige producten met een biologische basis. Dit wordt gerealiseerd door het opdoen van fundamentele kennis over biologische processen omtrent de ontwikkeling…

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Celebrating 20 years of Environmental Research and Education in Northern Cameroon

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

Deze opleiding integreert genetica, moleculaire biologie en biotechnologie in een aantrekkelijk programma met uitstekende carrièreperspectieven.

In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

In deze opleiding streef je naar het beantwoorden van biologische vraagstukken in relatie tot milieu, ecologie en andere maatschappelijk relevante onderwerpen.

In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Promotor: Richard D. Gill

In this thesis we study products of linear error correcting codes.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Promotores: S.J. Edixhoven, F. Andreatta

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

Promotor: S.J. Edixhoven, L.D.J. Taelman

An algorithm is discussed to compute the exponential representation of principal units in a finite extension field F of the p-adic rationals.

In this thesis three different topics in number theory are studied.

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

In this thesis, we explore a Hochschild homology and cohomology-like notion for logarithmic schemes.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

In dit onderzoek worden orde isomorfismen en orde antimorfisme bestudeerd in het algemene kader van partieel geordende vector ruimten.

This thesis is based on five papers on several topics.

Promotor: H.W. Lenstra

This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.

We prove a p-adic version of the work by Gross and Zagier on the differences between singular moduli by proving a set of conjectures by Giampietro and Darmon, who investigated the factorisation of a rational invariant associated to a pair of CM-points on a genus zero Shimura curve, obtained as the ratio…

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

Data theory research on the analysis on the multidimensional data

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Promotor: S.J. Edixhoven

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.