Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotie

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Op deze pagina vind je de opnames van de Tuesday Talks sinds april 2025. Ook de opnames van de voorloper van de Tuesday Talks, This Week’s Discoveries, zijn hier te vinden

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Promotor: A. Kros

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Hoe kunnen we efficiënte chemische synthese en klinische microbiologie combineren om nieuwe antibiotica tegen Clostridioides difficile-infecties te ontwikkelen?

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

Volg een keuzevak in beeldende kunst, design of muziek!

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Promotor: A.P. IJzerman

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

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