Promotor: Prof.dr. G.R. de Snoo

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: P.D. Grünwald

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Universiteit Leiden blijft graag in contact met haar alumni. Contactgegevens houden we daarom graag up-to-date. Blijf op de hoogte van het laatste nieuws voor alumni en ontvang uitnodigingen voor alumni-evenementen op het juiste (mail)adres.

Promotor: Prof.dr. P. Stevenhagen

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: Prof.dr. M. Danhof

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

This research focuses on the distribution of chemical elements in protoplanetary disks, the birthplaces of planets. These disks form around young stars and contain gas and dust, from which planets grow. Ice plays a crucial role in planet formation, aiding the clumping of dust particles and influencing…

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Artful Mathematics: The Heritage of M. C. Escher

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Promotores: A.H. Meijer, H.P. Spaink