Up to 45% of patients with Parkinson's disease experience impulse control disorders, characterised by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development…

Buikpijn is een veelvoorkomende klacht bij kinderen en jongeren. Zo'n 10 procent van de schoolgaande kinderen heeft er regelmatig last van.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

De Universiteit Leiden is met een 64ste plaats de hoogst genoteerde Nederlandse universiteit in de Times Higher Education Ranking (THE). Leiden stijgt drie plaatsen ten opzichte van vorig jaar. THE rangschikt op onderwijs, onderzoek en innovatie.

Machine Learning is becoming a more and more substantial technology for industry.

Leiden en Den Haag zijn echte studentensteden die van jouw studententijd een onvergetelijke tijd maken. Lees snel verder waarom.

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The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Explore "Regression Analysis" at Boerhaave Nascholing. Gain expertise in biostatistics methods for accurate data interpretation. Read more here.

Explore "Regression Analysis" at Boerhaave Nascholing. Gain expertise in biostatistics methods for accurate data interpretation. Read more here.

De pijnlijke geschiedenis van koloniale slavernij is lang onderbelicht gebleven. Mensen van wie de voorouders in slavernij leefden stellen nu kritische vragen over hoe we met dat verleden omgaan. Leidse onderzoekers bestuderen het koloniale en slavernijverleden en de langetermijnimpact daarvan op koloniaal…

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

Lezing

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Hot rocky exoplanets are planets that orbit so close to their host star that they possess a molten surface.

Promotor: H.J.M. de Groot

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: Prof.dr. L.J. Slikkerveer

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?