Let A be a commutative algebraic group over a field K, and let G be a finitely generated subgroup of the K-rational points of A. The purpose of this thesis is to study the degrees of the Kummer extensions relative to A,K and G.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

We simuleren interstellaire wolken met speciale plasma-expansies en chemische reacties op ijzige stofdeeltjes in ultrahoogvacuümopstellingen. Dit levert gegevens die nodig zijn om astronomische waarnemingen te interpreteren en de reactienetwerken in de ruimte te modelleren.

Broedplaats voor innovatie en ondernemerschap.

Eduard Fosch-Villaronga en Hadassah Drukarch van eLaw - Centrum voor Recht en Digitale Technologie, publiceerden onlangs het boek 'AI for Healthcare Robotics', uitgegeven door CRC Press van Taylor en Francis Group in hun AI for Everything-serie.

Het boek 'Fit for the future' bundelt de bijdragen van Leidse wetenschappers en behandelt de uitdagende onderwerpen op de agenda van het Nederlandse EU-voorzitterschap 2016.

Commerciële bedrijven die gebruik willen maken van de expertise en faciliteiten worden doorverwezen naar LAB , de commerciële eenheid die verantwoordelijk is voor gespecialiseerd laboratoriumwerk.

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

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Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Promotie

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: Prof.dr. P. Stevenhagen

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Het Europees Platform, de Nuffic, CINOP en het Nederlands Jeugd Instituut (NJI), vervullen samen de rol van het nationaal agentschap voor het Erasmus+ fonds van de Europese Commissie.

In november is het project ‘Academie voor Professionals’ van start gegaan. Hierin wordt ingezet op de verdere ontwikkeling van bestaand en nieuw onderwijsaanbod voor professionals. ‘Als je valorisatie serieus neemt dan hoort dit er gewoon bij.’

Kunst en vrije tijd, Kunst en vrije tijd

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

In onze opleidingen rondom Publiek Leiderschap verken je nieuwe benaderingen om de leiderschapsrol in complexe vraagstukken succesvol richting te geven, nu en in de toekomst. Op het snijvlak tussen theorie en praktijk leer je van wetenschappers en ervaringsdeskundigen. Deze leergangen zijn ontworpen…

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Het Leiden University Centre for the Arts in Society (LUCAS) is wereldwijd een van de weinige onderzoeksinstituten waar wetenschappers op het gebied van literatuur, beeldende kunst, architectuur, design en mediastudies samenkomen om onderzoek te doen naar de culturele productie van de westerse wereld,…

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The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.