The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: A.P. IJzerman

Promotor: F.J. van Lunteren, E. Jorin

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: B. van de Water

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Als alumnus van de Universiteit Leiden kunt u uw hele leven lang gebruik blijven maken van de Universitaire Bibliotheken Leiden (UBL).

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.

In 2024 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.

Dit was het programma van De Kennisboomgaard 2025:

Mensen met een licht verstandelijke beperking (LVB) bevinden zich dikwijls in een soort niemandsland. Door de diversiteit van hun problemen doen deze mensen een beroep op uiteenlopende hulpverleningsinstanties van waaruit ze weer worden doorverwezen. Hierdoor krijgen ze vaak niet de ondersteuning die…

De faculteit biedt een internationale academische omgeving met 36% van de studenten, promovendi en onderzoekers uit het buitenland.

Bekijk de toelatingseisen voor MSc International Organisation aan Universiteit Leiden in Den Haag. Inclusief benodigde 80 ECTS, Engelse taalnormen (IELTS/TOEFL) en ondersteunende documenten.

Zowel binnen ons biomedisch als ons biologisch onderzoek gebruiken we proefdieren. Lees hier welk onderzoek dit precies is en wat we met dat onderzoek willen bereiken.

When you have decided to participate in a Summer School of Leiden University, there are some matters you need to know before arrival. Please take a few minutes to read through the information here to find out what you can do from your side to smooth the process.

Lange tijd wisten we ons thuis in een wereld die we meenden te hebben. Het bestaan in deze vertrouwde wereld vormde onze existentie, die we op een eigenlijke wijze op ons namen. Thans is de wereld echter niet meer wat hij was, en zijn we ook zelf niet meer wie we waren. ‘De wereld is weg’, zo dichtte…

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Ook in 2020 hebben veel van onze medewerkers en studenten mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.