The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

We consider the propagation of electrical signals through nerve fibres.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

Promotor: P.D. Grünwald

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotor: K.J. Batenburg

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Hoe verandert generatieve AI de manier waarop we leren, communiceren en de wereld van vandaag begrijpen? Nu AI-tools deel uitmaken van het dagelijks leven, produceren ze niet alleen tekst, maar geven ze ook betekenis, beïnvloeden ze vertrouwen en hebben ze invloed op hoe we informatie vinden en delen.…

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).

This dissertation advances automated negotiation by developing agents that can learn and adapt across diverse negotiation settings through three increasingly sophisticated approaches: automated algorithm configuration, portfolio-based strategy selection, and end-to-end reinforcement learning with graph…

Het onderzoek van de afdeling Economie is ondergebracht bij meerdere facultaire programma's. Het onderzoek van de afdeling richt zich thans met name op sociaal-economische vraagstukken, rechtseconomie en fiscale economie.

Promotie

Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Zojuist verschenen: Nederlands internationaal privaatrecht Special issue: Private international law and finance

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotores: G.A. Persoon, H.H. de Iongh

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…