De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

Supervisor: Gerard van Westen

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Source: ChemMedChem (2015)

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Supervisor: Gerard van Westen

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Leiden University is ending the experiment with the Binding Study Advice in the second year of the bachelor's programme (BSA 2) with immediate effect. Under the terms of BSA 2, students were required to obtain 90 credits within two years, including their first-year diploma.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

During the course of drug discovery translational steps are made.

Voting Advice Applications represent popular election campaign tools in many countries, enabling voters to discover which party or candidate provides the best match with their political preferences. Political scientists Martin Rosema (University of Twente) and Tom Louwerse (Leiden University) examine…

Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Science for Sustainable Societies offers an exciting combination of theory and practice. While analysing and examining relevant topics from both the natural and the social sciences domains, you will also gain lots of hands-on experience. Interactive learning and working together in a team are important…

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

As a university, we offer you the best education you can get. Professors, tutors and lecturers are ready to teach and guide you. But we do more than that. Of course, studying is your own responsibility, but we are happy to help if you need support. You decide what and when; online or on campus. These…

The second major collection of papers from the Bridging the Unbridgeable project.

On this page you can find answers to frequently asked questions.

On this page you will find all information about the Bachelor of Security Studies that you need as a first-year student.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Intelligence scholars have been struggling to find the conditions under which international intelligence cooperation occurs. Most focus on transactional motives and guaranteed returns, the so called ‘Quid pro Quo’. At the same time, trust is often mentioned as one of the foremost conditions, yet it…

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

Studying International Relations and Organisations (IRO) you will address transboundary issues from a social sciences point of view. It is an international 3-year programme with a strong focus on current global affairs.

Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

This project analyzes to what extent hodegetical textbooks relied on each other in warning their readers against vicious habits, how much continuity their catalogs of vice displayed, and to what extent vices that persisted throughout the 18th and 19th centuries were associated with easy-to-remember…

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

From 3-6 December 2019 the conference “The Ties that Bind”: Mechanisms and Structures of Social Dependency in the Early Islamic Empire will take place. Deadline for sending in your abstract: 31 January 2019.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

The tree-year bachelor's programme in Archaeology is a many-sided programme in which you study societies, cultures, and human behaviour from the past, aiming to reconstruct and revive them. Dive into the development of human societies all over the world, from the Netherlands to the Mediterranean, and…

How can the university decide which partners to work with and why? This is a question many of us have, both within and outside our community. The advice presented by the Temporary Committee on Assessing Ethical Aspects of Collaborations should provide answers.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Promotor: M. Ubbink, Co-promotor: G. Siegal

‘Huis van het Boek/Museum Meermanno in The Hague exhibits book bindings by leading Dutch Art-Nouveau artists from the period 1890-1910. The exhibition will be open from March 22 to June 23 2019. The title of the exhibition is De Bijzondere Band: Art Nouveau-boeken van Dijsselhof, Lion Cachet en Nieu…

A quarter of all Dutch students suffer burn-out symptoms, and an even greater percentage regularly experience emotional exhaustion and tiredness. At a symposium on 7 May students were given tips for handling stress.

A special find has been made in the Alkmaar Regional Archive: a number of 17th-century book bindings contained pieces of parchment from a manuscript from the 11th century. The original manuscript may have belonged to a princess who fled England after the Norman Conquest.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)