Born in Europe roughly 100 years ago, quantum physics brought forth a veritable technological revolution through semiconductors, lasers, fibre optics, and many other technologies that are today ubiquitous in our lives. Now, during the second quantum revolution, Europe can take the lead once more in…

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

How can efficient chemical synthesis and clinical microbiology be combined to identify new antibiotics against Clostridioides difficile infections?

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.

Over time, the temperature in all buildings will be regulated in a sustainable manner. In this way, using gas will not be necessary anymore.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

In this thesis we present several methods to automate tomographic reconstruction algorithms and several novel tomographic reconstruction algorithms with the focus on being easily applicable and efficient to use.

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

On 24 November 2015, Prof. Carsten Stahn participated as external expert in a special plenary session of the Assembly of States Parties on the efficiency and effectiveness of Court proceedings, chaired by the co-chairs of the Study Group on Governance of the Assembly.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

To develop good cancer treatments, we need to know much more about how malignant tumour cells develop. Professor Ewa Snaar-Jagalska looks at not just the effect of medication on isolated cells but also the behaviour of cancer cells in their tissue environment. Inaugural lecture on 11 December.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Reinforcement learning is a framework that enables agents to learn in a manner similar to humans, i.e. through trial and error. Ideally, we would like to train a generalist agent capable of performing multiple tasks and achieving various goals.

Can bacteria be engineered to convert methanol into valuable chemicals with high efficiency?

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

The recently promoted Hao Wang from the Leiden Institute of Advanced Computer Science teaches computer programmes how to solve real-world problems. His goal is to make the process of problem-solving more efficient. On 1 November, he obtained his doctorate with the predicate cum laude. ‘I hope to solve…

On 28 September the famous chemists Carolyn Bertozzi visited Leiden University to speak at the LED3 seminar. Just one week later, she was announced winner the 2022 Nobel Prize in Chemistry. Leiden chemists Sebastian Pomplun and Hermen Overkleeft are fan: ‘We are extremely honoured to have hosted this…

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Promotor: A. Kros

Sharing scientific data, transferring money, or sending other sensitive information online: with cryptography, applications make sure your data does not fall into the wrong hands. Mathematician Thomas Attema (CWI/TNO/Leiden University) helps with this. For his PhD research, he developed a new technique…

Scientists have long been puzzled why it is easier to produce hydrogen from water in an acidic environment than in an alkaline environment. Marc Koper comes with an explanation: the reason is the electric field at the surface of the catalyst, which is larger in an alkaline environment, as he writes…

Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.

Research of the Leiden Institute of Chemistry into the development of a sustainable fuel cell has accidentally resulted in an exceptionally efficient catalyst for the production of hydrogen peroxide. The catalyst, discovered by Dennis Hetterscheid and PhD candidate Michiel Langerman, may lead to a more…

As of 1 October Rob van Nieuwpoort is the new professor of Efficient Computing and eScience at the Leiden Institute of Advanced Computer Science (LIACS). Van Nieuwpoort brings with him a wealth of expertise: he is an expert in eScience, high performace computing and advanced algorithms.

It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…

More efficient use of phosphorus fertilisers would make it possible to meet food demand in 2050, without using more of the world’s land for agriculture. This is what environmental scientists José Mogollón and colleagues have discovered by working out various future scenarios for food production and…

After hard work in the lab, Chemist Tirong Guo has developed a group of materials that provide a stable and efficient foundation for artificial photosynthesis. Will this enable the large-scale production of hydrogen and other useful compounds in the most sustainable way possible? Guo will defend her…

The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Many pharmaceutical companies no longer have their own lab and are working more closely with universities and start-ups of scientists. Professor of Science-Based Business Simcha Jong is researching how scientific ideas result in new drugs, including at the Leiden Bio Science Park (LBSP).

On Tuesday 10 March 2015 - 10h Ernst Worrell, professor at the University of Utrecht with a chair on

In mid-March 2020, the global coronavirus outbreak changed everything in the Netherlands. Staying at home as much as possible and the 1.5 metre rule became the standard. One year on, we reflect on the past year with four Leiden Law School ‘insiders’. What kind of year did they have? And what are their…

A tenacious postdoc researcher persuaded Professor Marc Koper to research the oxygen reduction reaction. In Koper's eyes, there was little of interest there. But they promptly discovered a whole new way to improve fuel cells on hydrogen and oxygen. Their article appeared in Nature Catalysis on 07 Ju…

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

Bjørn Peare Bartholdy is Archaeology’s representative in the Open Science Community Leiden (OSCL) . We spoke with him about the value of Open Science and how to make a good start. ‘Open Science is headed to be a regular way of academic work.’ So better to jump on the Open Science bandwagon early on.

How might we include circularity into the models often used in IPCC reporting (in technical language, how can IAMs, dMFA models and CGE models be integrated?) What are possible futures for global resource use and what are the consequences for greenhouse gas emissions in these scenarios?

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

Physicist Remko Fermin from Leiden University was awarded a Rubicon grant from NWO. He will use it to study superconducting diodes that could contribute to reducing the CO2 emission of data centres.

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.