Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

The aim of this research was to develop an effective, generative, and practical approach to enhance students’ structure-property reasoning (SPR).

Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

With defending his thesis ‘Applications of topology to Weyl semimetals and quantum computing’, the Leiden theoretical physicist Tom O'Brien has gained the rare 'cum laude' qualification. The freshly minted PhD has started a five year research programme on quantum algorithms for quantum chemistry, funded…

An international team of laboratory astrophysicists and astrochemical modellers has shown that glycine, the simplest amino acid and an important building block of life, can form under the harsh conditions that govern chemistry in space. The results have been published this week in Nature Astronomy and…

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

Promotor: Prof.dr. E. Bouwman

This thesis studies theoretical surface chemistry within the field of heterogeneous catalysis.

Professor Hermen Overkleeft has received the esteemed Roy L. Whistler International Award in Carbohydrate Chemistry for 2024 by the International Carbohydrate Organization. The award recognises Overkleeft’s outstanding contributions to the field of carbohydrate chemistry and biochemistry.

Andreas Bender, Assistant Professor for Medicinal Chemistry in the Medicinal Chemistry Division of the Leiden / Amsterdam Center for Drug Research, received the

With Sylvestre Bonnet, Jeroen Codée and Remus Dame, the Leiden Institute of Chemistry (LIC) will be getting no less than three new professors. Bonnet will become professor in Bioinorganic Chemistry, Codée professor in Organic Chemistry and Dame professor in Molecular and Cellular Biochemistry.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

A common assumption in chemistry is that the coordination number of a catalyst's surface determines the reactivity of the reaction it catalyses. Strikingly, Leiden chemists have now proven that this is not true for nature’s most simple chemical reaction: the dissociation of hydrogen. The researchers…

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

How can we understand the material instability of photographic (mixed media) artworks (1960s - present) from an integrated approach of Art History, Conservation Science and Chemistry in order to preserve these works for the future?

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

On March 27th, 2015 the biannual Dutch Medicinal Chemistry Prize for the best Dutch Ph.D. thesis in the field was awarded to Dr. Dong Guo, a current postdoc researcher in our lab, by the Section of Medicinal Chemistry of the Royal Netherlands Chemical Society.

PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Department of Civil Procedure Law.

Department of Notarial Law.

Department of Civil Law.

Department of Private International Law.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…