The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Op donderdag 17 april 2025 neemt prof. dr. Marco Mostert, Hoogleraar Middeleeuwse Geschiedenis aan de Universiteit Utrecht afscheid.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

De overheid moet in een democratie openbaarheid nastreven, maar soms is geheimhouding noodzakelijk om belangen als veiligheid of privacy te beschermen. De Wet open overheid (WOO) bevat daarom een recht op overheidsinformatie, maar staat ook uitzonderingen daarop toe om in de wet gespecificeerde belangen…

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

The Directorate-General Police, Sanctions, and Protection has initiated this research project in order to gain insight in the nature and, if possible, the extent of the developments with regards to the pluralization of policing functions in the Netherlands in support of future policies for the benefit…

During the course of drug discovery translational steps are made.

An international partnership of brain researchers from 35 research centres - from the US to China - including the Leiden Institute for Brain and Cognition (LIBC), has collected resting-state functional MRI data from more than 1400 healthy volunteers and put the information online so that it is available…

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

In her book Between Smiles and Grimaces, Mariska Kret shows us what differences there are between humans and animals, and more importantly, what similarities.

Our research regularly receives attention in the (Dutch) popular media. Here is an overview.

We prove a p-adic version of the work by Gross and Zagier on the differences between singular moduli by proving a set of conjectures by Giampietro and Darmon, who investigated the factorisation of a rational invariant associated to a pair of CM-points on a genus zero Shimura curve, obtained as the ratio…

Assuming everywhere good reduction we generalize the class number formula of Taelman to Drinfeld modules over arbitrary coefficient rings.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Jens Iverson, Assistant Professor of International Law and a Researcher in the Jus Post Bellum Project, defended his Ph.D. dissertation on 21 September 2017.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

On Thursday 30 May 2024 Corrie van Maris successfully defended a doctoral thesis and graduated.

This research will focus on the relationship between the musical structure and musical time in the performance of 19th century music.

On 7 November 2018, Catherine Harwood defended her thesis 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. The doctoral research was supervised by Prof. dr. L.J. Van den Herik and Prof.…

Een minderheid van de uithuisgeplaatste kinderen keert terug naar hun ouders, blijkt uit onderzoek van Universiteit Leiden. Hoogleraar jeugdrecht Mariëlle Bruning sprak met verschillende nieuwsmedia: ‘Alles staat zo onder druk dat te weinig ingezet kan worden op intensieve hulp.’

WhatsApp-gebruikers kunnen door een koppeling tussen systemen voortaan berichten sturen naar contacten op andere chatapps. Belle Beems, universitair docent Europees recht, zegt voor de NOS dat Europese regelgeving vereist dat communicatie tussen verschillende chatdiensten makkelijker wordt gemaakt.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

On the 15th of July Sawako Takemura successfully defended a doctoral thesis and graduated.

For the first time, a group of international and interdisciplinary researchers led by Karline Janmaat and her former MSc Student Chirag Chittar, have tested the several hypotheses on music simultaneously in a modern foraging society during their daily search for tubers – their staple food. They found…

What are the precise identities, possibilities and current practice examples of the various time frames in music and what bearings do they have individually and in combinations on the speed of the music?

Promotor: E.F. Smets Co-promotor: J. Geml

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

The aim of this thesis was to study the link between hearing loss, language skills, and social functioning in deaf and hard of hearing (DHH) children. Sufficient language skills are an essential prerequisite to develop appropriate communication skills, in order to join in conversations with others.…

This study is the first to directly relate brain development to sex differences and school performance. The results debunk the myth that brain development is slower in boys.

The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…