We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

This dissertation focuses on the systematic vowel alternations displayed by the Proto-Germanic n-stems. The fact is, that many of these nouns now appear to have preserved the ablaut system of the Indo-European proto-language spoken some five millennia ago. In this respect, the n-stems are truly comparable…

What is life like after a stem cell transplant? Haematologist Jennifer Tjon and nurse practitioner Kyra Oosterink from the LUMC are studying how patients experience recovery and what support they need.

Improved molecular knowledge of the mechanisms of processes in the cell can lead to better medicines and new or advanced methods for combating diseases. Our MSc students in Life Science and Technology (LST) specifically learn to understand the molecular and structural chemical and biological aspects…

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Promotor: Prof.dr. R.M.H. Merks

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

This thesis examines strategies to address the global threat of antimicrobial resistance (AMR). Antimicrobial resistance poses an increasing global health risk, highlighting the need for new treatments against Gram-negative pathogens.

Organ-on-chip technology is used in drug research and customized treatments for patients. Research Institutes and industry join forces within the Institute for human Organ and Disease Model Technologies (hDMT) that was officially launched on May 18. Combining facilities, people and expertise will allow…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: J. Kuiper

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The Business, Technology & Public Policy research group of the Department of Business Sciences at Leiden University focuses on investigating the dynamic interaction between 'new' technologies and various stakeholders, including consumers, employees, and businesses. Our research delves into perceptions,…

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

The Creative Intelligence & Technology master's programme (previously Media Technology) at Leiden University focuses on creative exploration as well as the understanding of science and technology.

Medical technology has become an essential part of healthcare. Innovative treatment methods therefore require a new type of medical professional. Someone with medical and technical knowledge, who builds a bridge between technology and patient.

'Technology, law and justice' is one of Leiden Law School's four research focus areas.

Are you eager to bring your own questions and curiosity into scientific research? Do you question intelligence and technology in a fundamental, creative, and playful way? Could you be a researcher who challenges scientific practice and pushes its boundaries?

Our courses embrace developments in technology. Our teachers adapt technological innovations to their discipline, and we keep our teaching up to date on rapid developments in the digital world.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

On 29 June 2017, Carl Mair defended his PhD dissertation “Taking Technological Infrastructure Seriously”. The supervisors are Professor A. Schmidt and Professor G.J. Zwenne.

Are you thinking about studying Creative Intelligence & Technology (previously Media Technology)? Learn more by watching our introduction video and the recordings of our talkshows and Q&A's from the Online Master's Open Days. The one from 10th Nov is with lecturer Edwin van der Heide and two of our…

Are you thinking about studying Life Science and Technology? Learn more and watch the introduction video.

Chemistry is all around us: from nutrition and smartphones to medicine. The field is developing rapidly, as the world population continues to grow and resources become scarce. MST will educate you on the basics of working towards a clean and healthy world.

Quantum Information Science & Technology is a new joint degree master programme by Leiden University and TU Delft. Below you can find a video of the campus of the Science Faculty of Leiden University where a part of the lectures will take place. A video about the programme's content and structure…

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The Laboratory for Material Science, Technology and Culture (MATEC Laboratory) is a research and teaching facility dedicated to the scientific and cultural study of archaeological materials. We bring together a multidisciplinary team working at the intersection of materials science, archaeology, and…

How can the law provide legal safeguards for the save introduction of quantum technology for consumers, and how can these safeguards be examined and interpreted through interdisciplinary collaboration?

Technological advances, such as virtual reality, augmented reality and online assessment platforms are rapidly improving. These tools could potentially contribute to neuropsychological assessment that is more efficient and of higher quality.

The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

Quantum Information Science & Technology (QIST) encompasses the understanding, design, construction and investigation of quantum information processing systems, such as quantum computers, quantum communication networks, and quantum sensors.

How can we connect quantum technology and society for an open debate on its future implications and applications?

Within the MAC our Enabling Analytical Technology team is working to innovate all steps of analytical workflows. This includes developing novel sample preparation modules, creative sample handling methods, automated workflows, and more. Several projects implement the microfluidic principle of segmented…

The Technology and Operation Management (TOM) group focuses on the operational challenges of adopting new cutting-edge technologies in areas such as artificial intelligence, precision medicine, and high-tech instrumentation.