Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotores: W. Jiskoot, F. Ossendorp

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

Traditional biochemical methods for studying organelles require cell disruption, preventing the real-time observation of dynamic intracellular processes.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

Heart failure is a major health care problem with high mortality.

Do babies and toddlers thrive more in a noisy or quiet day care centre? Research by specialist in Education and Child Studies Claudia Werner shows that children feel most comfortable in an environment where there is a little noise. With this kind of research, the method of analysis is very important.…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Being a better neighbour to the nature around you

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

A 90+ seat room in the LUMC Main Building. Rolling, flexible, tables on a carpetted floor allows for the quiet re-arrangement of the room to support teaching in groups of many size. Nearly 3 full walls are covered in magnetized, writable surfaces, and there are hinged TVs on the walls which can be beamed…

Old Observatory, Sterrenwachtlaan 11, 2311 GW, Leiden

The Dutch Royal Couple received 70 scientists at the yearly gala for the Diplomatic Corps at the Royal Palace in Amsterdam on 14 June 2023.

A consortium of researchers from the Leiden Institute of Physics (LION), the Institute of Biology Leiden (IBL), and the Leiden Institute of Chemistry (LIC) received a FOM program grant to develop a novel way of studying individual proteins inside a cell using gold nanorods.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Leiden biophysicist Stefan Semrau was granted an NWO Vidi earlier this month. He will use the grant to study the role of electricity in embryonic development and tissue regeneration.

Promotor: Prof.dr. T. Schmidt

The NIMAR library receives visiting students and affiliated researchers who are looking for a quiet place to study and work. Besides this, the library provides them with support in finding relevant literature for their research.

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

‘Regenerative medicine’ explores ways to repair or replace damaged cells, tissues and organs with cell, stem-cell or gene therapy. It can lead to valuable breakthroughs in the treatment of chronic diseases such as diabetes, heart problems and kidney diseases or muscle diseases.

The Cardiovascular Pharmacology research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Repairing organs, tissues and cells to fight chronic diseases.

An overview of the research at the Cancer Dug Target Discovery group.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.