Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

A neurobiological perspective on individual differences in social competence

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Honorata Mazepus, Assisstant Professor at Leiden University, researched the topic of Madisonian Judgments in Five Cultures, together with three other authors.

University is often a period of sexual exploration and experimentation, generally to the satisfaction of all involved. But sometimes you want it and the other doesn’t. Or vice versa. Or you can’t really tell. This is what the Safe Space play at Theater Ins Blau was about on 11 October. And: can your…

It is sufficiently plausible that, during her employment, a professor of archaeology at Leiden University was guilty of prolonged transgressive and unacceptable behaviour, ‘which also at that time could be classed as unacceptable’.

This is a difficult time. Above all, for all those directly involved in this horrible case – unacceptable behaviour by a professor and his removal from the University – the case we went public about on 18 October and that has been reported in the media. This is painful and tough for the complainants…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Please note that the course Molecular Biology for Physics will start on Monday 5 February. Please check the schedules for the time and location!

The researchers examine the Council of the European Union's voting behaviour between 2010 and 2021 and the impact of different independent variables.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

A professor from Leiden University has subjected various colleagues to intimidating and unacceptable behaviour for a longer period. These are the findings of an investigation carried out by the University’s independent Complaints Committee for Unacceptable Behaviour at the request of the Executive Board…

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

How does invasive hybridization affect threatened native species?

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

The Faculty of Social and Behavioural Sciences has become a lot healthier, thanks to the first Healthy Faculty event on 29 and 30 October, 2015. Health Psychology master’s students organised workshops for both students and staff. Many of them attended these inspiring workshops and already put the gained…

Receiving welfare benefits has a major impact on criminal behaviour. This has been demonstrated by Marco Stam, who defended his thesis on 20 January 2022.

A study on the development of prosocial behaviour.

New research published in the Journal of Leukocyte Biology suggests that these changes to the behavior of the immune system are persistent and can continue even after diet is improvedAlmost everyone knows that improving your eating habits will most likely improve your health. What most people may not…

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

On the 1st of October a new project funded by the Joint Industry Programme (JIP) started at the IBL on the potentially negative effects of sound on fish. Behavioural biologist and bioacoustic specialist Dr. Hans Slabbekoorn leads the international research team.

Mapping the neural mechanisms underlying social motivations of adolescents and adults

This thesis introduces the concept of

Political scientists Joop van Holsteyn and Tom Louwerse (Leiden University) find that the Dutch government is having a hard time coping with referendum outcomes in general, and ‘anti-European’ sentiments among voters in particular.

Toward optimal measurement and greater understanding of youth cognition in school refusal and cognitive behavioural therapy outcome

Political scientists Tom van der Meer, Lisa Janssen (University of Amsterdam) and Tom Louwerse (Leiden University) analyse polls presented by the main polling agencies in the Netherlands, as well as micro-level panel data. They reach three main conclusions. First, vote intention polls in the Netherlands…

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.