Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

Het proefschrift omschrijft de chemische synthese van fenolische glycolipiden van verschillende mycobacteriën met het doel om deze te kunnen gebruiken voor immunologisch onderzoek.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

The explanation from physicist Scott Waitukaitis for the screaming and bouncing gel balls in a hot pan has been covered in several media, including the Washington Post.

The skin has recently gained attention within body studies for its many specific cultural and social associations, in addition to its biology. This project aims to examine the different layers of meaning and the functions invested in the skin in ancient Greece: how did ancient Greek literary and medical…

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The MSc programme Physics offers 5 research-oriented specialisations where you can focus on Theoretical Physics, Quantum Matter and Optics, Biological and Soft Matter, or Cosmology. You can also combine Physics with education, management or science communication.

Lecture

Stam defended his dissertation ‘Freedom of speech and the suppression of discrimination in the Netherlands: a constitutional-developmental approach’ on 12 November 2025. The doctoral research was supervised by Afshan Ellian and Bastiaan Rijpkema

igraph development focused on improving the most-used interfaces, which are Python, R, and Mathematica. Additionally, the developers aim to make the library and the interfaces easier to maintain, focusing on long-term sustainability. This ensures that igraph continues to be a useful tool for network…

A defining fixture of our contemporary world, video games offer a rich spectrum of engagements with the past.

To log into many university systems you now need to use Multi-factor authentication (MFA). This means that as well as entering your username and password, you also need to confirm your identity via an additional method.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

The LUMC Flow Cytometry Core Facility accommodates all research and diagnostic flow cytometry equipment of the LUMC.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.

In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based…

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

Mechanical interactions between cells and their environment play an important role in many biological processes.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…

Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.

Are you interested in one of our vacancies? To get to know each other well, we follow a number of steps in the application process.

When you have finished your dissertation, it is time to prepare for the defence procedure.

It is important for social animals to be able to recognise one another quickly. Humans are able to recognise each other immediately from their faces. Faces are also important for chimpanzees, but a new study by neuropsychologist Mariska Kret in PLOS ONE shows that the animals' buttocks also play a…

We have recently discovered that there are biological proteins that phase separate out of solution much the way oil will de-mix from water (see movie). These form dense, liquid-like phases called protein condensates.

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

Exploring the synergy of light therapy and exposure psychotherapy to enhance PTSD treatment outcomes.

At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.