Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Have you ever stood in front of an abstract artwork and thought: “a monkey could have done that!”. As it turns out, you are wrong.

LIACS organizes different lectures and seminars like the LCN2 Seminars and SAILS Lunch Time-seminars.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: Prof.dr. M. Ubbink

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Promotor: M.A.G.J. Orrit

Promotores: W. Jiskoot, F. Ossendorp

On the 23rd of March, Alessandro del Tomba successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Alessandro on this achievement!

The experimental approach of science applied to artistic research

This thesis studies theoretical surface chemistry within the field of heterogeneous catalysis.

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In this article, published on the website SAGE research methods, authors Jaroslaw Kantorowicz and Tobias M. Hlobil discuss how a Regression Discontinuity Design can be executed.

The immune system plays an important role in the development of atherosclerosis, the underlying cause of cardiovascular diseases. Thomas van der Heijden has discovered that immunosuppressants may play a preventative role. PhD defence 19 December.

On 29 January 2019, Robbert van Eijk defended his thesis 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. The doctoral research was supervised by Prof. dr. H.J. van den Herik.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Knowledge and culture subproject 2:

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

Pathways of toxicity

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

Does powerlessness and dependence lead to the legitimation of the social, political, and economic status quo and of those in authority?

Imagining Urban Complexity introduces passionate and critical perspectives on the link between the humanities and urban studies.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Promotor: Prof.dr. E.F.A. Deprettere, Co-promoter: Todor P. Stefanov

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

Can small molecule drugs restore the immune system’s ability to fight tuberculosis by boosting autophagy?

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotor: Prof.dr. E. Bouwman