The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

Psycho-physiological studies for health and disease.

A new therapy for the serious Graft-versus-Host disease

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

Iranian molecular plant biologist Salma Balazadeh started her career in Germany. Now she sets up a research group in Leiden to study stress in plants to secure global food supply. Her outlook on women in science in the context of the International Day for Women and Girls in Science, 11 February.

Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.

Professor Jaap Dubbeldam passed away on the 19th of November at his home in Leiderdorp.

The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

Mirjam van Reisen favours big data built up from local inputs in developing countries and suitable for local use. The new Professor of Computing for Society at Leiden's Faculty of Science connects data science with development sociology. Inaugural lecture 10 March.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Repairing organs, tissues and cells to fight chronic diseases.

PhD defence

As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.

On this page you will find an overview of awards and prizes granted to our staff and students in 2024, as well as special appointments at Leiden University and other institutions.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

The goal of pre-clinical development is to bridge the transition from lead compounds to clinical candidates by comprehensively characterizing safety, efficacy, and pharmacological properties. Once a lead compound demonstrates promising activity in disease models, it enters pre-clinical development where…

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the track-specific courses, the elective courses, a research internship and a thesis.

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Medicine with Haramaya University in Ethiopia.

Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.

Eight scientists from Leiden University have been awarded a grant by the Dutch Research Council (NWO). With this Vidi funding, the researchers can set up an innovative line of research and further expand their own research group over the next five years.

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Control of infectious diseases poses continuous challenges for human health.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

This research investigates the impact of socioeconomic developments on the physical condition of medieval populations in Holland and Zeeland between AD 1000 and 1600 through the analysis of human skeletal remains from three archaeological sites.

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

An overview of research themes and projects at ABS.

The master’s programme of Bio-Pharmaceutical Sciences at Leiden University examines the research area of bio-pharmaceutical sciences and drug research. It offers seven specialisations ranging from BioTherapeutics to Industrial Pharmacy.