1,585 search results for “complex system in” in the Public website
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Large Time Behaviour of Neutral Delay Systems
Promotor: S.M. Verduyn Lunel
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Overlapping institutions in the UN human rights system: Mutually strengthening or undermining?
Valentina Carraro explores the relationship between overlapping UN human rights institutions, specifically the treaty bodies and the Universal Periodic Review (UPR)
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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sentencing: a homicide case flow analysis of the Dutch criminal justice system
Homicide engenders broad moral concerns in society, and its aftermath can be understood as a barometer for criminal justice policy. Of all homicides committed, however, only some lead to arrest, to prosecution and ultimately to conviction in court.
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Citizenship? Collective Food Procurement in European Cities in "Food, food systems, and agriculture"
Grasseni's contribution to this special feature on food cultures, food systems, and agriculture in Europe builds upon her ongoing project Food citizens? Collective food procurement in European cities: solidarity and diversity, skills and scale.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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PhD candidates in their own words
The Data Science Research Programme at Leiden University combines data science with PhD projects in a wide range of disciplines. The programme has been running for over two years, and is producing the first astonishing results. A number of PhD candidates talk about their experiences and research bel…
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Scientific understanding and provision of an enhanced and robust monitoring system for Responsible Research & Innovation (RRI)
Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…
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Polypept(o)ide-based Cylindrical Polymer Brushes as Multifunctional Drug Delivery Systems
The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Kristian Rietveld
My research area is the field of Computer Systems. More in particular, my research interests are high performance computing (HPC), performance analysis and optimization, parallel and distributed computing, and optimizing compiler techniques. Simply put, I am fascinated by all kinds of techniques that…
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Education & Training
At CWTS, we offer a range of educational and training activities designed to equip students, researchers, and professionals with the skills and knowledge to better understand the science system and its interactions with society.
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Who’s next?: The role of speech melody in the turn-taking system of Dutch
When we are in a conversation, how do we know exactly when to respond, and how do we manage to respond so swiftly, yet without interrupting our interlocutors? Can speech melody – in particular utterance final “boundary tones” – help us determine who will speak next, or are these cues too late in the…
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policy-making; the contribution of think tanks to policy advisory systems
Think tanks have proliferated in most Western democracies over the past three decades and are often considered to be increasingly important actors in public policy. Still, their precise contribution to public policy remains contested.
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Oliver Taherzadeh
Oli is an environmental economist studying the sustainability of global food systems with a focus on transitions of diets, food trade, and farmer livelihoods.
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Hai Lin
Lin obtained his PhD from Delft University of Technology in 1993. After graduation (ir.) in Applied Mathematics at Delft University of Technology.
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Agent Based Modelling for Archaeologists (ABMA)
The Agent Based Modelling for Archaeologists (ABMA) project is dedicated to developing Open Educational Resources (OERs) and accompanying materials for agent-based modelling (ABM) in Archaeology.
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Global Soil Biodiversity Atlas
For a first time the atlas maps the soil biodiversity of the entire planet, and provide s comprehensive analysis of human-induced threats to soil organisms and soil functioning, facilitating development of new policies to protect soil and soil organisms.
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Frank Takes
My main fundamental research interest is computational network science. I focus on methods and algorithms for knowledge discovery from (social) network data. Through various projects, I also work on real-world applications, e.g., corporate networks, networks in economics, finance, science, infrastructure…
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Akrati Saxena
Akrati Saxena leads the Algorithmic Fairness (AlFa) research group and is a member of the Computational Network Science (CNS) group at LIACS. Her research interest lies at the intersection of Social Network Analysis, Complex Networks, Computational Social Science, Data Science, and Algorithmic Fairn…
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self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Politics: Mapping Alternatives to SWIFT in a Fragmenting Global Financial System
Every time we pay for something, our money moves through global technical systems that connect the world economy. These systems are convenient, but they also expose users to Western sanctions, prompting countries like Russia to look for alternative financial infrastructure.
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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sustainability of NdFeB magnet recycling: foresight study on recycling systems and technologies
The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.
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HomininSpace – a large scale simulation system for hominins in the past
HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Low-Energy Electron Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems
On 14 November 2019, Luis Fiallos Pazmino defended his thesis 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. The doctoral research was supervised by Prof. P.M.J. Mendes de Leon and Prof. E.C.P.D.C. De Brabandere.
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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The Chicago system: a steadfast legal blueprint for world civil aviation?
On the occasion of the 80th anniversary of the magna carta of civil aviation, the Convention on International Civil Aviation (Chicago Convention 1944), Professor Steven Truxal has written a leading piece for the European Civil Aviation Conference: The Chicago system: a steadfast legal blueprint for…
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Labor movements and party system development: Why does the Caribbean have stable two-party systems, but the Pacific does not?
How can we explain that Caribbean small states have the most stable two-party systems in the world, while Pacific small states have either very weak parties or no parties at all? Matthew Louis Bishop (University of Sheffield, UK), Jack Corbett (University of Southampton, UK) and Wouter Veenendaal (Leiden…
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Handbook of Signal Processing Systems
Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…
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Aysegül Çelik
Aysegul started as a PhD candidate at the Industrial Ecology department of CML in September 2025. Her research focuses on Actor-level Food System Footprinting for a sustainable food transition.
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Jennifer Anderson
Jennifer started as a PhD researcher at the Industrial Ecology department of CML in September 2022.
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Fatemeh Mehrafrooz Mayvan
Fatemeh is a PhD student at LIACS, specializing in Hardware security and Embedded systems. In 2022, she earned her master's degree in computer architecture from Sharif University of Technology, Tehran. During her studies, she conducted research on optimizing load balancing for IoT and edge devices using…
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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investigation of the photoprotection mechanism of Light Harvesting Complex II
Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.
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A brain-wide map of neural activity during complex behaviour
A key challenge in neuroscience is understanding how neurons in hundreds of interconnected brain regions integrate sensory inputs with previous expectations to initiate movements and make decisions.
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Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics
In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.
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Exploration on and of Networks
This dissertation consists of two parts, with the common theme
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Is it time to amend Dutch work disability system?
The research report by the independent committee on the future of the work disability system in the Netherlands ('Onafhankelijke Commissie Toekomst Arbeidsongeschiktheidsstelsel' (Octas)) was published this week. While the number of people unable to work has dropped considerably, the system is still…
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…