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1,276 search results for “bioactieve molecular” in the Public website

• 
  YAO Yao Researcher

  Faculty of Science

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  Zoë Vogelaar Research staff member

  Faculty of Science

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  Lisa de Koning PhD candidate

  Faculty of Science

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  Nashanty Brunken PhD candidate

  Faculty of Science

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  Yuan Chen PhD candidate

  Faculty of Science

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  Thierry Shema Analyst

  Faculty of Science

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  Mirjam Huizenga Postdoc

  Faculty of Science

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  Volkert van Steijn Director of Education / Guest

  Faculty of Science

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  Marissa Vlasblom PhD candidate

  Faculty of Science

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  Arina Belov PhD candidate

  Faculty of Science

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  Floor Stevens Analyst

  Faculty of Science

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  Khaled Essa PhD candidate

  Faculty of Science

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  Milou Temmink PhD candidate

  Faculty of Science

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  Tamara Mocking Postdoc

  Faculty of Science

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  Rob Bosman Postdoc

  Faculty of Science

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  Bert Beerkens Guest

  Faculty of Science

• 
  Michael Meijer Education coordinator bachelor MST

  Faculty of Science

• 
  Jana Volaric Postdoc

  Faculty of Science

• 
  Xinyu Di Guest researcher

  Faculty of Science

• Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B Research output

  Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

• Dynamics of a β-lactamase Research output

  BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

• Strategy Cell Systems and Drug Safety

  The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

• Natural and non-natural factors influencing Alzheimer´s Aβ Research output

  Promotor: Prof.dr. J.P. Abrahams

• Dr Heiko Vogel Symposium on Insect-Plant Interactions 2021

• Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation Research output

  Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

• Expertise Centre for Interdisciplinary Genome Research

  The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

• Dark ice chemistry in interstellar clouds Research output

  This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

• Responding to environmental cues: the adaptive qualities of chromatin compaction proteins Research output

  Promotor: M. Ubbink, Co-Promotor: R. T. Dame

• Prof Dr Marcel Dicke Symposium on Insect-Plant Interactions 2021

• From stress to success; How actinobacteria exploit live without a cell wall Research output

  The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

• Control of Western flower thrips through jasmonate-triggered plant immunity Research output

  We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

• Evolutionary diversification of Nepenthes (Nepenthaceae) Research output

  Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

• Programme structure Molecular Genetics and Biotechnology (MSc)

  Through courses and research projects, you are trained by experts in the field.

• Evolution of Biodiversity Hortus botanicus Leiden

  One of the main research focuses of the Hortus botanicus Leiden is to study how the current biodiversity we see today, has originated, changed, and developed over time. The Hortus wants to study the relationship between species in specific focal taxa and see how they have diverged over time.

• Multifunctional polypept(o)ide miktoarm star polymers for advanced drug delivery: from the development of versatile synthetic strategies for Research output

  With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

• Synthetic peptides as tools in chemical immunology Research output

  This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

• Environmental and metabolomic study of antibiotic production by actinomycetes Research output

  Promotor: Prof.dr. G.P. van Wezel

• Insights from modeling metabolism and amoeboid cell motility in the immune system Research output

  This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

• Computational Biology Research project

  Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

• Systematics and Biogeography of the Dissochaeta alliance (Melastomataceae) Research output

  Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

• Translational Neuroscience Research project

  Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

• Off the wall: characterisation and exploitation of a cell wall deficient life style in filamentous actinomycetes Research output

  Almost all bacteria are enveloped by a cell wall that provides cellular protection.

• Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation Research output

  The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

• 'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology Research output

  An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

• Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology Research output

  The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

• The role of autophagy during carbon starvation in Aspergillus niger Research output

  Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

• Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines Research output

  Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

• Teaching Molecular Physiology

  At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

• A Herbig disk view of planet formation Research output

  In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

• Chemical biology of antigen presentation by MHC molecules Research output

  MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.