Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Promotor: Prof.dr. M.L. van Hecke

In de Flow Cytometry Core Facility van het LUMC is alle onderzoeks- en diagnostische flowcytometrieapparatuur van het LUMC ondergebracht.

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

This thesis describes a study from both a theoreticaL and an experimental point of view.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

World history is often framed in terms of flows of people and migration: humans coming ‘out of Africa’, the spread of farmers in the Holocene, Phoenician and Greek diasporas over the ancient Mediterranean, the colonization of the world by Europeans from the 16th century onwards. Together with his Exeter…

De Leidse onderzoeker dr. Ben Zonneveld heeft de grootte van het genoom – de hoeveelheid DNA per kern - van wilde tulpen bepaald. Zijn conclusie is dat er meer dan 87 wilde soorten zijn. Verschillende mogelijk nieuwe soorten zijn ontdekt.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Een groot deel van het gebruikte of verspilde textiel van de EU wordt geëxporteerd naar landen met lagere inkomens. Een groot deel van dit geëxporteerde textiel wordt verbrand of gedumpt en de hoeveelheid die daadwerkelijk wordt hergebruikt of gerecycled is onzeker.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Consequences for sediment stability and seston trapping

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Promotor: Prof.dr.ir. E. Deprettere

Leidse onderzoekers hebben aanwijzingen gevonden waarom een zeldzame zwangerschapsziekte bij sommige baby’s mild verloopt en bij andere levensgevaarlijk is. De vondst opent de deur naar een test die ernstige gevallen al tijdens de zwangerschap kan opsporen. Een behandeling bestaat gelukkig al.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.