The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Het onderzoeksprogramma Probability Theory richt zich op kansrekening en op operationeel onderzoek.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In this thesis we examine certain phenomena in symplectic topology which are related to the theory of isolated singularities.

Het onderzoek binnen het Algebra, Geometry and Number Theory programma varieert van fundamentele wiskundige theorie tot algoritmes en toepassingen.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

In de masterspecialisatie Algebra, Geometry and Number Theory verbreed je je kennis van de zuivere wiskunde met onderwerpen als getaltheorie, algebraïsche meetkunde, algebraïsche topologie en cryptologie.

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

This six-weeks online course delves into the research behind terrorism as it unpacks the assumptions and impacts of both terrorism and counterterrorism.

Ontdek de MSc Political Theory: Legitimacy and Justice aan Universiteit Leiden — verdiep je in rechtvaardigheid en legitimiteit, bestudeer klassieke en moderne politieke filosofie en ontwikkel je analytische en filosofische vaardigheden.

Promotor: J. Zaanen

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Bekijk de opbouw van de MSc Political Theory: Legitimiteit en Rechtvaardigheid aan Universiteit Leiden: kernvakken, keuzevakken, methodenvakken, scriptie of stage, en kleinschalige seminars.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Ontdek de MSc Political Theory: Legitimiteit en Rechtvaardigheid aan Universiteit Leiden — met focus op politieke filosofie, diepgaande theorievakken, keuzevakken, en afsluiting met scriptie of stage.

Promotor: Prof.dr. G.P. van Wezel

Bekijk de toelatingseisen voor de MSc Political Theory: Legitimacy and Justice aan Universiteit Leiden — bachelordiploma in (of verwant aan) Politicologie met voldoende relevante studiepunten en, indien nodig, methodologische achtergrond.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Ontdek waarom Universiteit Leiden dé plek is voor de MSc Political Theory: Legitimiteit en Rechtvaardigheid — met toponderwijs in politieke filosofie, kleinschalige seminars en deskundige docenten.

Ontdek de extra uitdagingen bij de MSc Political Theory: Legitimacy and Justice aan Universiteit Leiden — zoals de Honours Academy, leadershiptrainingen en extra onderzoeks- of verdiepingstrajecten.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Ontdek de carrièremogelijkheden na de MSc Political Theory: Legitimacy and Justice — denk aan loopbanen in onderzoek, beleidsanalyse, maatschappelijke debatten, ethiekadvies of vervolgstudie (PhD).

In deze studie onderzoeken we of 2-3-jarigen in staat zijn te anticiperen op het gedrag van een personage door rekening te houden met wat dit personage wel of niet weet over de situatie. Het kind zit op schoot en krijgt animaties te zien met twee personages, waarbij de ene zich verstopt en de andere…

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…