Promotor: B. van de Water, Co-promotor: E.H.J. Danen

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Promotie

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Promotores: T.H. Oosterkamp, N. de Jonge

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Patients share valuable advice and experiences with their peers in online patient discussion groups.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Promotie

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

Promotor: Prof.dr. J. Kuiper

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Promotie

Promotie

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

De Haarlemse burgemeester Jos Wienen zit ondergedoken vanwege bedreigingen uit onbekende hoek. Onderzoeker Ruth Prins sprak erover in het televisieprogramma Na het nieuws.

Op 19 oktober organiseerde het Centrum voor Recht en Digitale Technologie van de Universiteit Leiden (eLaw) de eerste jaarlijkse Hans Franken-lezing. De lezing;

Het grootste consultancyprogramma van de universiteit, het PRINS programma van International Studies, verbindt al zes jaar internationale werkgevers met geesteswetenschappenstudenten. Oprichter Sarita Koendjbiharie: ‘Studenten International Studies bieden de holistische blik die complexe, maatschappelijke…