Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Antibioticaresistentie is een van de grootste bedreigingen wereldwijd voor de volksgezondheid in de komende decennia.

Understanding how nature captures and transfers solar energy is essential both for elucidating biological photosynthesis and for guiding the design of artificial light-harvesting systems.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Oratie

Duurzaamheid is een van de centrale aandachtspunten van de Universiteit Leiden en speelt een steeds grotere rol binnen het onderwijs en onderzoek van de Faculteit der Rechtsgeleerdheid. Binnen deze context levert de afdeling Sociaal Recht een belangrijke bijdrage aan het debat en onderzoek rondom Business…

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Human AI is waar kunstmatige intelligentie en machine learning samenkomen met filosofie, cognitieve wetenschap en de creatieve kunsten. Voorbeelden van onderzoeksvragen in dit domein zijn: ‘Kan een algoritme naar menselijke maatstaven creatief zijn?', 'Kunnen creatieve processen, zoals het componeren…

This thesis examines strategies to address the global threat of antimicrobial resistance (AMR). Antimicrobial resistance poses an increasing global health risk, highlighting the need for new treatments against Gram-negative pathogens.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

In dit artikel stelt Tom Buitelaar een systematisch kader voor om het effect van individuele kenmerken van vredeshandhavers op het gedrag van grondpersoneel bij VN-vredesoperaties te analyseren.

In de serie Humans of Humanities, lichten wij iedere twee weken een van onze wetenschappers, medewerkers of studenten uit.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Van zelfrijdende auto’s tot innovatieve medicijnontwikkeling, kunstmatige intelligentie (AI) gaat ons leven op uiteenlopende manieren fundamenteel veranderen. Onze computerwetenschappers bestuderen de technologie op een diep en fundamenteel niveau. Maar we zoeken ook naar medische toepassingen en antwoorden…

There is no human society that does not employ a rich and diverse language. This course introduces you to linguistics, featuring interviews with well-known linguists and with speakers of many different languages. Join us to explore the miracles of human language!

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Het LUMC iPSC Hotel biedt de generatie van research grade humane geïnduceerde pluripotente stamcellen (iPSC's) uit verschillende weefselbronnen met behulp van de modernste herprogrammeringstechnieken.

Melanie Fink, Postdoctoraal Onderzoeker bij het Europa Instituut van de Universiteit Leiden, heeft haar boek Frontex and Human Rights, Responsibility in 'Multi-Actor Situations' under the ECHR and EU Public Liability Law gepubliceerd. Dit boek is gebaseerd op haar proefschrift, dat zij in december 2017…

Leiden University’s Master of Law in European and International Human Rights Law (L.L.M.) looks at the various protection mechanisms applied to human rights across different political, social and cultural settings.

Heart failure is a major health care problem with high mortality.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Woensdag 13 december verdedigde Melanie Fink haar proefschrift ‘Frontex and Human Rights: Responsibility in “Multi-Actor Situations” under the ECHR and EU Public Liability Law’.

Promotor: Prof.dr. M. Danhof

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Op 21 januari 2020 verdedigde Patrick van Berlo zijn proefschrift 'Human Rights Elephants in an Era of Globalisation: Commodification, Crimmigration, and Human Rights in Confinement'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. van der Leun en prof.mr.dr. M.A.H. van der Woude.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

The Encyclopedia of Global Human Migration biedt een complete verkenning van de prominente thema's, gebeurtenissen en theoretische onderbouwingen van de verplaatsingen van menselijke bevolkingsgroepen van de prehistorie tot heden.

Kom naar onze online en oncampus events om ons beter te leren kennen!

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer