Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

Promotores: T.H. Oosterkamp, N. de Jonge

De onderzoeksgroep Governance of Crises bestudeert fenomenen, dynamieken en actoren die te maken hebben met crisisgovernance. Het Crisis Research Center (CRC) van de Universiteit Leiden maakt deel uit van deze onderzoeksgroep.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: Prof.dr. E. Deprettere

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

Dit proefschrift richt zich op vragen over het doel van onderwijs en wat het betekent om opgeleid te zijn. Deze vragen zijn tijdloos, aangezien de antwoorden op deze vragen altijd in zekere mate verband houden met de hedendaagse samenleving.

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Veel mensen binnen de Universiteit Leiden zijn verbonden aan Academia in Motion.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Doordat markten in toenemende mate zijn geïnternationaliseerd, zijn (sub-)nationale toezichthouders ook steeds vaker internationaal actief. Binnen vormen van internationale netwerksamenwerking wisselen deze toezichthouders onderling informatie uit en onderhandelen ze over internationale standaarden…

Promotor: Prof.dr. F. den Hollander, G.Maillard

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

This thesis applies data mining in commercial settings in the telecommunications industry.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

De Engelstalige master Biomedical Sciences in Leiden gaat over het bestuderen van normale en abnormale processen in het menselijk lichaam. Zo leer je ziektes beter te begrijpen, bestaande therapieën te verbeteren of nieuwe therapieën te bedenken. Naast het algemene programma dat zich toespitst op het…

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Promotor: E.F. Smets Co-promotor: J. Geml

De Faculty of Governance and Global Affairs

Het onderzoek van de Intelligence and Security Studies Group naar inlichtingen en veiligheid draagt bij aan academische kennis, voedt de publieke discussie, ondersteunt ons onderwijs en de ontwikkeling van professionele praktijk.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

Promotor: A. Kros

Artful Mathematics: The Heritage of M. C. Escher

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.