Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Doordat markten in toenemende mate zijn geïnternationaliseerd, zijn (sub-)nationale toezichthouders ook steeds vaker internationaal actief. Binnen vormen van internationale netwerksamenwerking wisselen deze toezichthouders onderling informatie uit en onderhandelen ze over internationale standaarden…

Promotor: Prof.dr. F. den Hollander, G.Maillard

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

This thesis applies data mining in commercial settings in the telecommunications industry.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

De Engelstalige master Biomedical Sciences in Leiden gaat over het bestuderen van normale en abnormale processen in het menselijk lichaam. Zo leer je ziektes beter te begrijpen, bestaande therapieën te verbeteren of nieuwe therapieën te bedenken. Naast het algemene programma dat zich toespitst op het…

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Promotor: E.F. Smets Co-promotor: J. Geml

De Faculty of Governance and Global Affairs

Het onderzoek van de Intelligence and Security Studies Group naar inlichtingen en veiligheid draagt bij aan academische kennis, voedt de publieke discussie, ondersteunt ons onderwijs en de ontwikkeling van professionele praktijk.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

Promotor: A. Kros

Artful Mathematics: The Heritage of M. C. Escher

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

In de onderzoekslijn Geneesmiddelenonderzoek werken we voornamelijk met knaagdieren. Knaagdieren, zoals muizen, worden veel gebruikt als proefdier. Deze kleine zoogdieren zijn makkelijk te houden en planten zich snel voort.

The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.

Promotores: G. Persoon, R. Schefold

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Deze uitgave is het eerste integrale overzichtswerk op het gebied van fraude en fraudebestrijding waarin wetenschappers én praktijkmensen de belangrijkste aspecten van fraude, fraudepreventie en fraudebestrijding analyseren. Erwin Muller en Pinar Ölcer, beiden werkzaam bij het Instituut voor Strafrecht…

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

This thesis utilises the exceptional sensitivity and resolution of LOFAR to explore the low-frequency Universe, while simultaneously advancing the telescope's capabilities to enable new scientific discovery.

De Leergang Public Affairs biedt een sterke basis voor professionals in de overheid, het bedrijfsleven of maatschappelijke organisaties die actief zijn in het beïnvloeden van besluitvorming en beleid.

De Leergang Cybersecurity is bedoeld voor ambtenaren die (gaan) werken aan digitale veiligheid binnen ministeries of decentrale overheden.

Deze training is speciaal ontwikkeld voor jou als professional, als:

Promotor: Prof.dr. E. Smets, M. Stech

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: J. Aarts

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis