Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotie

Werken vanuit boeiende en relevante taken

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Promotor: B. van de Water

Promotor: B. van de Water

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.

Met een perspectiefgerichte benadering van onderwijs worden kennis, vaardigheden en houding van leerlingen met elkaar verbonden.

De studieonderdelen die betrekking hebben op het functioneren van studenten in de onderwijspraktijk zijn Praktijk 1 (eerste deel van de opleiding) en Praktijk 2 (tweede deel van de opleiding).

Het ICLON doet onderzoek naar het basis- en voortgezet onderwijs.

Perspectieven zouden het fundament van een toekomstbestendig curriculum in alle onderwijssectoren moeten zijn

Didactiek

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

De focus van dit proefschrift is het leren en de samenwerking van docenten in het voortgezet onderwijs.

Voorstellen voor onderwijsvernieuwing hebben doorgaans weinig impact op de onderwijspraktijk. Zijn docenten dan zo recalcitrant of is er toch wat anders aan de hand?

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

In dit artikel analyseren Lydie Cabane en Martin Lodge analyseren de invloed van institutionele keuzes op het aanpassen van beleidsintegratie in grensoverschrijdende crisisbeheersing.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Frans in perspectief

Promotie

Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…

Stimuleren van Prestaties en Motivatie in de Eerste Jaren van het Voortgezet Onderwijs

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.