Promotor: P.D. Grünwald

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

Promotor: Prof.dr. T.H.W. Bäck

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

This dissertation consists of two parts, with the common theme

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Binnen Dappere Kleintjes werken we aan verschillende projecten om peuters en kleuters te helpen die snel angstig of verlegen zijn. We richten ons op het vroeg herkennen van angstig gedrag én op het ondersteunen van ouders om hier mee om te gaan.

This study’s main aim is to test whether children’s learning behaviour explains why they do not benefit from a literate environment.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Achter de schermen werken er veel verschillende mensen mee aan de projecten binnen de Dappere Kleintjes onderzoekslijn. Zie hieronder een overzicht van het onderzoeksteam.

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Promotores: R. Tijdeman, K.J. Batenburg

Quantum annealing belongs to a family of quantum optimization algorithms designed to solve combinatorial optimization problems using programmable quantum hardware. In this thesis, various methods are developed and tested to understand how to formulate combinatorial optimization problems for quantum…

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The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

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Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Het Centre for Public Values & Ethics (CPVE) is een interdisciplinair academisch expertisecentrum met als doel het verrichten en verspreiden van wetenschappelijk onderzoek naar waardengeladen vraagstukken in de publieke sector. In het bijzonder wordt gekeken naar de ethiek van de publieke ambtsvervulling…

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Dissociative chemisorption is an important reaction step in many catalytic reactions.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Sheltering is an immediate human need and determines well-being andhealth.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.

CMLCA is a software tool that supports the technical steps of the Life Cycle Assessment. The focus of the program is on advanced computational aspects of life cycle inventory calculations.

Promotor: Prof.dr. J.N. Kok

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

During the course of drug discovery translational steps are made.

Promotor: G. J. Kroes

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Promotor: A.W. van der Vaart

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

Promotor: Prof.dr. P. Stevenhagen, Co-Promotor: J.H. Evertse

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