660 zoekresultaten voor “cell mobility” in de Publieke website
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Structure uncovered: understanding temporal variability in perceptual decision-making
Studies naar perceptuele besluitvorming presenteren dezelfde stimulus doorgaans herhaaldelijk tijdens een experimentele sessie, maar negeren de volgorde van deze observaties, waarbij wordt uitgegaan van een onrealistische stabiliteit van beslissingsstrategieën tijdens proeven. Maar zelfs ‘stabiel’,…
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Celtypes in kaart gebracht van foetale nier
Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Onderwijs
De vakken die het VVI aanbiedt zijn onderdeel van het bredere onderwijsprogramma van de Faculteit der Rechtsgeleerdheid, dat programma’s aanbiedt op bachelor- (LLB) en masterniveau (LLM, Advanced Studies, PhD). Het instituut geeft een in Europa uniek MSc programma Law and Society: Governance and Global…
- Ontmoet onze docenten
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Genomics applications of nanopore long-read sequencing for small to large sized genomes
In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Single-electrolyte isotachophoresis: on-chip analyte focusing and separation
Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto
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Vacatures
Overzicht van de vacatures bij de afdeling Economie.
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Morphogenesis and protein production in Aspergillus niger
Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
- Onderzoeksoutput
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Immune cell networks in Inflammatory Bowel Disease
Promotie
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The aging B cell landscape in atherosclerosis
Promotie
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Exploring and exploiting CD8+ T cell proliferation
Promotie
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Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
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Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: W. Jiskoot, Co-promotor: A. Kros
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Applications for DNA-encapsulated silver clusters in physics, biology and medicine
We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
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Copper complexes for bioinspired electrocatalysis relevant to the reduction of oxygen
This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.
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Squaramide-based interpenetrated networks for load-bearing applications
This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.
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Subsidies
Wil je staf- en studentenuitwisseling en internationalisering een structurele plek geven in jouw onderwijs of onderzoek door middel van samenwerking met een buitenlandse universiteit?
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Sylvia Le Dévédec -
Niet langer naar de wereld kijken als ‘the West and the rest’
Kunsthistoricus en hoogleraar Kitty Zijlmans heeft een missie: ze wil af van het idee dat het westen de kunstwereld domineert. Niet langer ‘the West and the rest’, maar de uitwisseling tussen ideeën en culturen centraal stellen in de kunstgeschiedenis. ‘Dan zie je dat er zoveel uitwisseling geweest…
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Integration and disentanglement of single-cell and spatial transcriptomics with applications in Autosomal Polycistic Kidney Disease
Promotie
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Hoe uitzaaiende tumoren hun omgeving naar hun hand zetten
Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…
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Ahmed Mahfouz: 'Het mysterie van hersenziekten, cel voor cel uitgezocht'
Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.
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Drones schrijven mee aan nieuwe geschiedenis Cariben
Drones blijken een goed hulpmiddel om door de mens aangebrachte veranderingen in het landschap in kaart te brengen. Geofysicus Till Sonnemann en zijn collega’s (archeologie) experimenteren ermee in moeilijk doordringbare gebieden in de Cariben.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Investigating lipid formulations for efficient RNA delivery using zebrafish models
Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.