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893 zoekresultaten voor “clinical thijs” in de Publieke website

• Clinical Reasoning by Pharmacists Fostering Clinical Decision-Making and Interprofessional Collaboration in Pharmacy Practice and Education Agenda - 14 november 2025

  Promotie

• Studieprogramma Klinische Psychologie (MSc)

  De masterspecialisatie Klinische Psychologie bestaat uit drie delen: de verplichte en keuzevakken, een scriptie en een stage.

• Leerlijn Suïcidepreventievaardigheden: van onbewust onbekwaam naar bewust bekwaam Onderzoeksproject

  Een doorlopende leerlijn suïcidepreventie biedt psychologiestudenten essentiële kennis en vaardigheden om suïcidaliteit effectief te herkennen en het gesprek erover aan te gaan.

• 
  Anne van Giezen Universitair Docent

  Faculteit der Sociale Wetenschappen

• 
  Manja Koenders Universitair docent

  Faculteit der Sociale Wetenschappen

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  Mischa de Rover Universitair docent

  Faculteit der Sociale Wetenschappen

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  Julia van den Berg Docent /gast

  Faculteit der Sociale Wetenschappen

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  Ricarda Proppert Promovendus

  Faculteit der Sociale Wetenschappen

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  Taarique Debidin Docent

  Faculteit der Sociale Wetenschappen

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  Annelies Oskam Management/office-assistent

  Faculteit der Sociale Wetenschappen

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  Jacqueline Guicherit-Dicke Vaardigheidsdocent

  Faculteit der Sociale Wetenschappen

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  Esther Verwayen Vaardigheidsdocent

  Faculteit der Sociale Wetenschappen

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  Jens Henkelmann Vaardigheidsdocent

  Faculteit der Sociale Wetenschappen

• 
  Carlotta Rieble Promovendus

  Faculteit der Sociale Wetenschappen

• 
  Linda Tisseur Management assistent

  Faculteit der Sociale Wetenschappen

• 
  Johanna Greeven Docent

  Faculteit der Sociale Wetenschappen

• 
  Antonia Rulitschka Promovendus

  Faculteit der Sociale Wetenschappen

• 
  Boitumelo Vavani Promovendus

  Faculteit der Sociale Wetenschappen

• Modulation of leukocyte homeostasis in atherosclerosis Onderzoeksoutput

  Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

• The interplay between lipids and the immune system in atherosclerosis Onderzoeksoutput

  Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

• Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease Onderzoeksoutput

  This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

• Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children Onderzoeksoutput

  Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

• Novel regulators of prostate cancer stem cells and tumor aggressiveness Onderzoeksoutput

  Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

• The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and Onderzoeksoutput

  In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

• Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease Onderzoeksoutput

  The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

• Liposome-based synthetic long peptide vaccines for cancer immunotherapy Onderzoeksoutput

  Promotores: Wim Jiskoot; Ferry Ossendorp

• The road to insurmountability: Novel avenues to better target CC Chemokine receptors Onderzoeksoutput

  This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

• Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights Onderzoeksoutput

  Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

• Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis Onderzoeksoutput

  Prostate cancer (PCa) is one of the most prevalent cancer in males.

• Boosting the host immune system to fight tuberculosis Onderzoeksoutput

  New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

• Synthesis, structure and epitope mapping of well-defined Staphylococcus aureus capsular polysaccharides Onderzoeksoutput

  This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

• Systems pharmacology of the amyloid cascade Onderzoeksoutput

  According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

• The Function of Toll-like receptor 2 in Infection and Inflammation Onderzoeksoutput

  The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

• Lipids as therapeutic targets for barrier repair in skin diseases Onderzoeksoutput

  The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

• Advancing the LeiCNS-PK3.0 model for prediction of CNS Pharmacokinetics Nonlinear BBB Transport, Inter-species Scaling, and Machine Learning Onderzoeksoutput

  This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

• Robotic reconstitution of cytostatic drugs and monoclonal antibodies: transforming aseptic drug compounding in hospital pharmacies Onderzoeksoutput

  Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

• Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies Onderzoeksoutput

  Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

• Single-cell immune profiling of atherosclerosis: from omics to therapeutics Onderzoeksoutput

  Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

• Preclinical validation of putative targets in cardiovascular and metabolic disease Onderzoeksoutput

  Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

• First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children Onderzoeksoutput

  Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

• A cross-sectional study of early language abilities in children with sex chromosome trisomy (XXY, XXX, XYY) aged 1–6 years Onderzoeksoutput

  Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…

• Diagnosis and treatment of obese children with insulin resistance Onderzoeksoutput

  Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

• Microfluidic 3D cell culture for high throughput screening Onderzoeksoutput

  There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

• Exploring the chemical space of natural products from Streptomyces using multi-omics approaches Onderzoeksoutput

  The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

• The ins and outs of ligand binding to CCR2 Onderzoeksoutput

  Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

• Towards predictive cardiovascular safety: a systems pharmacology approach Onderzoeksoutput

  Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

• Evolvability and epistasis studied through the lens of an antibiotic resistance enzyme Onderzoeksoutput

  Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

• Quantitative pharmacology of antimicrobials Onderzoeksoutput

  Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

• Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting Onderzoeksoutput

  Promotor: Prof.dr. M. Danhof

• Novel Immune Cell-Based Therapies for Atherosclerosis Onderzoeksoutput

  Promotor: Prof.dr. J. Kuiper