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1,304 zoekresultaten voor “cell chemistry” in de Publieke website

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  Martin Sicho Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

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  Natalia Ortiz Zacarias Universitair docent

  Faculteit der Wiskunde en Natuurwetenschappen

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  Herman van Vlijmen Hoogleraar

  Faculteit der Wiskunde en Natuurwetenschappen

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  Brandon Bongers Gast Wetenschapper

  Faculteit der Wiskunde en Natuurwetenschappen

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  Daan van der Es Universitair hoofddocent

  Faculteit der Wiskunde en Natuurwetenschappen

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  Bart Lenselink Gast Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

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  Adriaan IJzerman Emeritus hoogleraar

  Faculteit der Wiskunde en Natuurwetenschappen

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  Bola Khalil Buitenpromovendus / gast

  Faculteit der Wiskunde en Natuurwetenschappen

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  Inge Snijders Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

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  Linde Schoenmaker Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

• Composition and function of integrin adhesions Onderzoeksoutput

  Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

• Unconventional fabrication of 2D nanostructures and graphene edges Onderzoeksoutput

  In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

• Deep Learning Solutions for Domain-Specific Image Segmentation Onderzoeksoutput

  Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

• Analysis of sub-visible particles in complex injectable formulations Onderzoeksoutput

  Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

• Metabolomics study of blood vessels-on-chip model Onderzoeksoutput

  Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

• More is alive: emergent multi-scale order & collective flows in tissues Onderzoeksoutput

  The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

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  Rafaël Vos Gast-onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

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  Haifeng Zhou Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

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  Roxanne Kieltyka Universitair hoofddocent

  Faculteit der Wiskunde en Natuurwetenschappen

• Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs Onderzoeksoutput

  Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

• Inhibitor Selectivity: Profiling and Prediction Onderzoeksoutput

  Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

• Dynamics of TNFalpha signaling and drug-related toxicity Onderzoeksoutput

  In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

• Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics Onderzoeksoutput

  In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

• Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes Onderzoeksoutput

  Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

• Onderzoeksfaciliteiten

• A chemical biology approach for targeting of ligand-drug conjugates Onderzoeksoutput

  Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

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  Thijs Voskuilen Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

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  Arjan de Koning Universitair docent

  Faculteit der Wiskunde en Natuurwetenschappen

• Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A Onderzoeksoutput

  Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

• Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing Onderzoeksoutput

  Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

• Inhibitors and probes targeting PslG Onderzoeksoutput

  Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

• Affinity-based profiling of the adenosine receptors Onderzoeksoutput

  The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

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  Sander van Kasteren Hoogleraar

  Faculteit der Wiskunde en Natuurwetenschappen

• A song of ice and gas: the formation and evolution of complex organic molecules Onderzoeksoutput

  Understanding how chemical complexity emerges during star formation requires connecting molecular material preserved in interstellar ices with that observed in the gas phase after protostellar heating begins.

• Samenwerken voor efficiënte medicijnontwikkeling Wetenschapsdossier

  De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

• Chemical Biology Onderzoeksproject

  Het chemische biologie-onderzoek bij het Leids Instituut voor Chemisch Onderzoek (LIC) is gericht op het begrijpen van biologische processen op moleculair niveau, om zo onze kennis te vergroten over gezondheid en ziekte van de mens.

• Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy Onderzoeksoutput

  In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

• Precision modeling of breast cancer in the CRISPR era Onderzoeksoutput

  The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

• CellEKT: a chemical proteomics platform to study the kinome Onderzoeksoutput

  Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

• Computational modeling of angiogenesis : from matrix invasion to lumen formation Onderzoeksoutput

  Promotor: Roeland M.H. Merks

• Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney Onderzoeksoutput

  Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

• The Function of Toll-like receptor 2 in Infection and Inflammation Onderzoeksoutput

  The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

• Ecological functioning of bacterial chitinases in soil Onderzoeksoutput

  Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

• Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum Onderzoeksoutput

  The applications of studying the early development of insects range from agriculture to material science.

• Antibiotic Discovery: From mechanistic studies to target ID Onderzoeksoutput

  The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

• Towards understanding the toxicity of copper nanoparticles in aquatic ecosystems Onderzoeksoutput

  Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

• The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions Onderzoeksoutput

  This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

• Photocleavable activity-based acid glucosylceramidase probes Onderzoeksoutput

  Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

• The role of the interleukin 12 family in atherosclerosis Onderzoeksoutput

  Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

• Key innate immune components controlling intracellular infection Onderzoeksoutput

  Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer