The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Zelfredzaamheid en sociale bescherming over de levenscyclus

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Cryptanalist Marc Stevens van het Centrum Wiskunde & Informatica (CWI) in Amsterdam, bekend van zijn 'kraak' van de MD5 hash-functie voor https-beveiliging in 2008, heeft deze week het recente Flame-virus geanalyseerd. Hij ontdekte dat voor deze spy malware een compleet nieuwe, tot nu toe onbekende…

Met het nieuwe studiejaar is bij de Honours Academy ook een nieuwe assessor aangetreden: Maarten Kolpa. Wat doet een assessor eigenlijk? En wat kan hij voor studenten betekenen? Maarten vertelt erover in een interview. “Ik vind het belangrijk dat het studentenperspectief vooropstaat.”

Ze vond alle studies interessant, maar koos voor Sterrenkunde. En nu ontrafelt hoogleraar Mariska Kriek de onstaansgeschiedenis van sterrenstelsels met de James Webb telescoop. KIJK-redacteur Laurien Onderwater praat met haar over haar over haar carrièrepad.

De oorlog in Oekraïne duurt inmiddels bijna twee weken. Wat denkt Poetin te bereiken met zijn inval en hoe groot is de kans dat het westen betrokken raakt bij de oorlog? We bellen erover met hoogleraar en Ruslandkenner André Gerrits.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

Kunst en vrije tijd, Kunst en vrije tijd

Na 25 jaar is het deze december eindelijk zo ver: de lancering van de lang verwachte James Webb ruimtetelescoop. Leidse astronomen kijken vol spanning mee: niet alleen waren zij betrokken bij de bouw van belangrijke instrumenten aan boord, de telescoop zal ook vele nieuwe geheimen van het heelal onthullen,…

Na 25 jaar is het deze december eindelijk zo ver: de lancering van de lang verwachte James Webb ruimtetelescoop. Leidse astronomen kijken vol spanning mee: niet alleen waren zij betrokken bij de bouw van belangrijke instrumenten aan boord, de telescoop zal ook vele nieuwe geheimen van het heelal onthullen,…

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Langetermijnontwikkelingen, zoals het verouderen van de bevolking, de toename in de gemiddelde levensverwachting en de gevolgen van de recente financiële crisis, hebben bijgedragen aan de discussie rondom de houdbaarheid van het pensioenstelsel.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: F. Arbab

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Promotor: P.D. Grünwald

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

We consider the propagation of electrical signals through nerve fibres.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.