Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Zelfredzaamheid en sociale bescherming over de levenscyclus

Exoplanets close in to their host star receive high levels of extreme ultraviolet (EUV) irradiation, capable of heating and ultimately driving the hydrodynamic escape of their atmospheres.

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.

Met het nieuwe studiejaar is bij de Honours Academy ook een nieuwe assessor aangetreden: Maarten Kolpa. Wat doet een assessor eigenlijk? En wat kan hij voor studenten betekenen? Maarten vertelt erover in een interview. “Ik vind het belangrijk dat het studentenperspectief vooropstaat.”

De oorlog in Oekraïne duurt inmiddels bijna twee weken. Wat denkt Poetin te bereiken met zijn inval en hoe groot is de kans dat het westen betrokken raakt bij de oorlog? We bellen erover met hoogleraar en Ruslandkenner André Gerrits.

Ze vond alle studies interessant, maar koos voor Sterrenkunde. En nu ontrafelt hoogleraar Mariska Kriek de onstaansgeschiedenis van sterrenstelsels met de James Webb telescoop. KIJK-redacteur Laurien Onderwater praat met haar over haar over haar carrièrepad.

Cryptanalist Marc Stevens van het Centrum Wiskunde & Informatica (CWI) in Amsterdam, bekend van zijn 'kraak' van de MD5 hash-functie voor https-beveiliging in 2008, heeft deze week het recente Flame-virus geanalyseerd. Hij ontdekte dat voor deze spy malware een compleet nieuwe, tot nu toe onbekende…

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

Na 25 jaar is het deze december eindelijk zo ver: de lancering van de lang verwachte James Webb ruimtetelescoop. Leidse astronomen kijken vol spanning mee: niet alleen waren zij betrokken bij de bouw van belangrijke instrumenten aan boord, de telescoop zal ook vele nieuwe geheimen van het heelal onthullen,…

Na 25 jaar is het deze december eindelijk zo ver: de lancering van de lang verwachte James Webb ruimtetelescoop. Leidse astronomen kijken vol spanning mee: niet alleen waren zij betrokken bij de bouw van belangrijke instrumenten aan boord, de telescoop zal ook vele nieuwe geheimen van het heelal onthullen,…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

In this thesis,

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

This thesis is about the study of hydrocarbons via infrared spectroscopy.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

Promotor: Prof.dr. C.W.J. Beenakker

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Promotores: Wim Jiskoot; Ferry Ossendorp

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

De meeste kinderen leren pas op de middelbare school Frans. Hoe leuk is het als ze al wat Franse woorden leren en kennismaken met de Franse cultuur op de basisschool? Dat kan via deze kennismakingslessen, gemaakt door studenten van de Universiteit Leiden.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotor: J.N. Kok, Co-promotor: M.S. Lew

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Heart failure is a major health care problem with high mortality.