1,709 zoekresultaten voor “have a” in de Publieke website
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Experience Day Leiden University College The Hague
Studievoorlichting, On Campus Experience
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Experience Day Leiden University College The Hague
Studievoorlichting, On Campus Experience
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: Prof.dr. J.N. Kok
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On the geometry of demixing: A study of lipid phase separation on curved surfaces
Like a mixture of oil and water, lipid membranes separate into two liquid phases.
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Early death of massive galaxies in the distant universe
Promotor: M. Franx, Co-Promotor: I.F. Labbé
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The evolution of shell form in tropical terrestrial microsnails
Promotor: Prof.dr. M. Schilthuizen
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The Diving Dutchman: het marien-gravimetrisch onderzoek van F.A. Vening Meinesz (1887-1966)
Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra
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Theory of mind in language, minds, and machines: a multidisciplinary approach
Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.
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Into the Darkness: Forging a Stable Path Through the Gravitational Landscape
In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.
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A time-space translation mechanism for patterning the vertebrate anteroposterior axis
My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.
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Superlattices in van der Waals materials: A Low-Energy Electron Microscopy study
n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.
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Comparative genomics of the balanced lethal system in Triturus newts
All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Towards a Structural Understanding of Plant─Microbiota Interactions using cryo-EM Techniques
The endophytic microbiota is a community of various microorganisms that reside in plant tissue. These microbes are known to promote plant health and resilience, and their members do not simply exist side by side.
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Isotopes and the characterization of extrasolar planets
Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.
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Gisela Hirschmann, Coronavirus: A Global Crisis Waiting for a Global Response
Vaak wordt gezegd dat een crisis iemands ware aard naar boven brengt. Het coronavirus stelt het multilaterale systeem op de proef. Politicoloog Gisela Hirschmann (Universiteit Leiden) maakt zich zorgen over de toekomst van internationale samenwerking.
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From Crisis to Inquiry: A Framework for Designing and Assessing Crisis Inquiries from a Learning Perspective
In dit artikel onderzoeken Wout Broekema, Wouter Jong en Sara Perlstein het ontwerp en de beoordeling van crisisonderzoeken vanuit een leerperspectief.
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A Feminine or Masculine Crisis? Gender Stereotypes and Leadership During a Pandemic
Kantorowicz onderzoekt hoe genderstereotypen de perceptie van leiderschapscompetentie beïnvloeden bij verschillende soorten crises.
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Developing a behavioural cybersecurity strategy: A five-step approach for organisations
Dit onderzoek presenteert een vijfstappenplan voor de ontwikkeling van een effectieve gedragsgerichte cyberveiligheidsstrategie.
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Coping with administrative tasks: A cross-country analysis from a street-level perspective
This study seeks to analyse how job stress could be the result of performing administrative tasks
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Weighting factors for LCA - A new set from a global survey
De auteurs presenteren een benadering voor het achterhalen van de voorkeuren van de bevolking voor gebruik in de optionele wegingstap in de Levenscyclusanalyse (LCA).
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Efficient tuning of automated machine learning pipelines
Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…
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Not so smooth after all: resolving dust and gas structures in protoplanetary disks
A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
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Picturing Intimacy: Mediation and Self-representation in a Boston’s Religious Festivals
Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Towards secure and sustainable supply chains: a multi-perspective risk assessment for photovoltaics
Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.
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Comparative biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Being a guest author for blogs/online reviews: why and how
How does one become a guest author for Nobel Prize winner Dr. Denis Mukwege Foundation? One of our alumni, Mariasole Forlani, can tell you all about it.
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Withstanding the cold: energy feedback in simulations of galaxies that include a cold interstellar medium
Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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Explicit Computation of the Height of a Gross-Schoen Cycle
Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.
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A chemical biology approach to explore lipid metabolism in neurological disorders
Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.
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Bearing with noise: The effects of highway noise on behaviour and development in zebra finches
Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.
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Experience Day BSc Security Studies
Studievoorlichting, Experience Day
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Attacks on hash functions and applications
Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger
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Transfer Learning in Deep Reinforcement Learning and Procedural Content Generation
In this dissertation (titled: Exploring the Synergies between Transfer in Reinforcement Learning and Procedural Content Generation) we explore how the two research fields named in the title, namely Transfer in Reinforcement Learning (TRL) and Procedural Content Generation (PCG) can synergize togethe…
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.