Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

There are study programmes at LIACS that offer the opportunity to do an internship or research project, as part of the curriculum.

How does one become a guest author for Nobel Prize winner Dr. Denis Mukwege Foundation? One of our alumni, Mariasole Forlani, can tell you all about it.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Promotor: Prof.dr. M.K. Richardson

Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Promotor: Prof.dr. B.R. Katzy

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotor: J. A. Bouwstra

Studievoorlichting

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

In this dissertation (titled: Exploring the Synergies between Transfer in Reinforcement Learning and Procedural Content Generation) we explore how the two research fields named in the title, namely Transfer in Reinforcement Learning (TRL) and Procedural Content Generation (PCG) can synergize togethe…

Promotor: F. Arbab

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Understanding how chemical complexity emerges during star formation requires connecting molecular material preserved in interstellar ices with that observed in the gas phase after protostellar heating begins.

Op 29 Juni 2017 heeft Doris Dull-Zessner haar proefschrift “Value Congruence in a Multinational Corporation” verdedigd. De supervisors zijn prof.dr.mr. J.A.A. Adriaanse and prof.dr. J.I. van der Rest.

Veel docenten in het voortgezet onderwijs houden rekening met verschillen tussen leerlingen. Uit het promotieonderzoek van Saskia Stollman (ICLON) blijkt dat zij hierbij ruimte om te experimenteren en ondersteuning van de school(leiding) nodig hebben.

Wout Broekema benadrukt dat organisaties niet alleen leren van crises, maar ook vergeten, waarbij cruciale kennis en werkwijzen verloren gaan.

This dissertation presents four separate chapters, all striving towards the same goal: to understand dynamic phenomena occurring in dynamic networks and to explore the emergence of equilibrium in a broad sense.

Individuen die werken in de publieke sector zien zichzelf geconfronteerd worden met tegenstrijdige waarden, tegenstrijdige eisen en de noodzaak van het dienen van het soms moeilijk definieerbare publieke belang.

Deze praktische gids informeert studenten over de taal en andere vaardigheden die nodig zijn om een presentatie in het Engels te geven. Deze bondige en toegankelijke gids is bijzonder behulpzaam voor leerders van het Engels.

Promotie

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

Promotor: J. Schaye

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Participants in this course will learn to support student teachers and new colleagues in their professional development as teachers, with particular emphasis on the context of bilingual or international education, as in the ICLON World Teachers Programme (WTP).

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…