Promotor: Prof.dr. M. Ubbink

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

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With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

De Leergang Cybersecurity is bedoeld voor ambtenaren die (gaan) werken aan digitale veiligheid binnen ministeries of decentrale overheden.

Het Instituut voor Privaatrecht bestaat uit vijf afdelingen: de afdeling Civiel Recht, het Hazelhoff Centre for Financial Law, de afdeling Jeugdrecht, de afdeling Notarieel recht en de afdeling Ondernemingsrecht.

Promotor: J. Aarts

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

Promotor: Prof.dr. P.C. van Welzen

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Lezing

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Binnen Quantum Leiden doen verschillende groepen onderzoek naar quantumnetwerken en quantumsensing.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: Prof.dr. M. Ubbink

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Hybride intelligentie (HI) is de combinatie van menselijke en machinale intelligentie, waarbij het menselijk intellect wordt uitgebreid in plaats van vervangen. HI houdt rekening met de menselijke expertise en intentionaliteit bij het nemen van zinvolle beslissingen en het uitvoeren van passende acties,…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Promotor: M.A.G.J. Orrit

Het emotionele gedrag begrijpen van anderen is essentieel voor het navigeren in het dagelijkse sociale leven. Maar hoe wordt zo'n begrip bereikt? De eye-tracking studie van Yung-Ting Tsou en collega's laat zien dat kinderen met gehoorverlies een unieke visuele strategie hanteren die gebruik maakt van…

Promotor: Prof.dr. J.W.M. Frenken

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

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