The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

In this work, we attempt to answer the question:

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Overzicht van de belangrijkste papyrologische websites

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Promotor: Prof.dr. D. Bouwmeester

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

Als alumnus van de Universiteit Leiden kunt u uw hele leven lang gebruik blijven maken van de Universitaire Bibliotheken Leiden (UBL).

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Promotor: M.A.G.J. Orrit

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Promotor: Prof.dr. J.W.M. Frenken

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Ben jij nieuwsgierig naar hoe wetenschap en technologie bijdragen aan een duurzame en innovatieve toekomst? Bij de Universiteit Leiden onderzoek je de wereld van data, natuurwetten en levende systemen. Van wiskunde tot kunstmatige intelligentie, van klimaatvraagstukken tot hightech innovaties: je leert…

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Promotor: Prof.dr. M. Ubbink

Binnen Quantum Leiden doen verschillende groepen onderzoek naar quantumnetwerken en quantumsensing.

Cryptocurrencies zijn geëxplodeerd op de mondiale financiële markten, waarbij de waarde van een enkele bitcoin is gegroeid van ongeveer 800 USD in 2016 tot 67.000 USD in 2021.

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Giles Scott-Smith, 'Interdoc. Een geheim netwerk in de Koude Oorlog' (Amsterdam 2012) Uitgeverij Boom.

Het emotionele gedrag begrijpen van anderen is essentieel voor het navigeren in het dagelijkse sociale leven. Maar hoe wordt zo'n begrip bereikt? De eye-tracking studie van Yung-Ting Tsou en collega's laat zien dat kinderen met gehoorverlies een unieke visuele strategie hanteren die gebruik maakt van…

Ben jij nieuwsgierig naar hoe wetenschap en technologie bijdragen aan een duurzame en innovatieve toekomst? Bij de Universiteit Leiden onderzoek je de wereld van data, natuurwetten en levende systemen. Van wiskunde tot kunstmatige intelligentie, van klimaatvraagstukken tot hightech innovaties: je leert…

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Onderzoek naar het precieze taal- en spraakgedrag van sprekers.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Hybride intelligentie (HI) is de combinatie van menselijke en machinale intelligentie, waarbij het menselijk intellect wordt uitgebreid in plaats van vervangen. HI houdt rekening met de menselijke expertise en intentionaliteit bij het nemen van zinvolle beslissingen en het uitvoeren van passende acties,…

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Studievoorlichting

Studievoorlichting