Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

This thesis applies data mining in commercial settings in the telecommunications industry.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotor: J. A. Bouwstra

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Grote telescopen kijken zo ver het heelal in, dat ze ook miljarden jaren terug in de tijd kijken. De opvolger van de Hubble ruimtetelescoop, de James Webb telescoop, zal vanaf 2018 zicht krijgen op de periode vlak na de Oerknal waarin de eerste sterren en sterrenstelsels ontstonden. Leidse astronomen…

Voor het eerst kan een internationaal team van wetenschappers onder leiding van de Sterrewacht Leiden en SRON de extreme straalstromen die rond de evenaar van alle reuzenplaneten worden waargenomen met één model verklaren.

Een timelapse van het universum met een hogere resolutie dan ooit tevoren. Dat is het doel van het NSF-DOE Vera C. Rubin Observatorium in Chili, dat op 23 juni zijn eerste beelden van het heelal onthult. Onderzoekers van de Leidse Sterrewacht hebben een belangrijke bijdrage geleverd aan de realisatie…

Lezing

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Op 4 december werd de exoplaneet aan de astronomische wereld gepresenteerd, die eind vorig jaar door drie Leidse studenten onder leiding van Ignas Snellen is ontdekt. Het blijkt een uniek object te zijn, een stuk groter dan Jupiter, en met bijna vijf keer zijn massa.

Promotor: A.P.IJzerman Co-promotor: A. Bender

In this thesis, we address two problems concerning the tautological rings of the moduli space of curves.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Hoe ontstaan sterrenstelsel? Daar gaat astronoom Mariska Kriek de komende jaren onderzoek naar doen. Ze krijgt een NWO Vici-subsidie van 1.5 miljoen euro om sterrenstelsels in het vroege heelal te bestuderen. ‘Dit onderzoek gebruikt nieuwe en ongekende waarnemingen van de James Webb-ruimtetelescoop…

In het programma ‘Atlas’ van NPO3 legt Mariska Kriek uit dat ze de James Webb- telescoop gaat gebruiken voor haar onderzoek naar sterrenstelsels die drie miljard jaar na de oerknal zijn ontstaan. Ook haar collega Marijn Franx is in de aflevering te zien. Beiden werken als hoogleraar Extragalactische…

Een internationaal team van sterrenkundigen onder leiding van Ardjan Sturm van de Sterrewacht heeft voor het eerst een tweedimensionale inventaris gemaakt van ijs in een planeetvormende schijf van stof en gas rond een jonge ster. Ze deden dat met de James Webb-ruimtetelescoop. De onderzoekers, onder…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

Promotor: Prof.dr. M. Ubbink

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

Het is de grootste structuur in het heelal: een duizelingwekkend web van materie dat sterrenstelsels zoals de Melkweg onderling verbindt. De Leidse Joop Schaye en Michael Maseda waren twee van de astronomen die hielp een piepklein stukje van dit 'kosmische spinnenweb' in beeld te brengen. In de Volkskrant…

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Promotor: F.J. van Lunteren, E. Jorin

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.