Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

NWO Chemische Wetenschappen heeft een TOP-PUNT subsidie toegekend aan een onderzoeksproject van chemicus prof.dr. Gijs van der Marel van de Universiteit Leiden en prof. dr. ir. A.J. Minnaard van de Rijksuniversiteit Groningen.

Hans de Bruijn studeerde cum laude af en schreef zijn onderzoeksplan tijdens een speciale masteropleiding voor getalenteerde chemiestudenten van de Holland Research School (HRSMC). Zijn voorstel werd gehonoreerd en De Bruijn start later dit jaar zijn door NWO en HRSCM gefinancierde promotietraject.

Om je aan te melden voor de bacheloropleiding Molecular Science and Technology heb je meerdere documenten nodig. Zorg ervoor dat je deze documenten bij de hand hebt.

Vier Leidse wetenschappers hebben een consolidator grant gekregen van maximaal 2 miljoen euro van de European Research Council (ERC). Ze doen onderzoek naar uiteenlopende onderwerpen, waaronder genderstereotypering bij exacte vakken en het maken van suikermoleculen.

Onder toeziend oog van familie en vrienden kregen 428 studenten hun Propedeusediploma’s uitgereikt, waarvan 103 studenten zelfs met cum laude.

Promotie

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

De Microscopy Unit huisvest, onderhoudt en coördineert vrijwel alle microscopieapparatuur van het IBL. De beschikbare apparatuur varieert van conventionele licht- en fluorescentiemicroscopen tot confocale laser- en elektronenmicroscopen. Er is bovendien apparatuur beschikbaar voor histologie, met inbegrip…

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: Prof.dr. M. Ubbink

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotor: Prof.dr. J.P. Abrahams

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Voor Molecular Science and Technology is de matchingsactiviteit een verplicht onderdeel van de inschrijving.

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.