One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

MST biedt verschillende voorlichtingsactiviteiten –zowel in Leiden en Delft- om je te helpen bij je studiekeuze.

Studievoorlichting

Na de master kiezen de meeste alumni voor een baan in het bedrijfsleven of bij de overheid.

Datawetenschapper Lindsey Burggraaff heeft de tweede editie van de Krijn Rietveld Memorial Innovation Award gewonnen. Ze ontvangt de prijs voor haar onderzoek naar zogeheten bio-actieve stoffen in voeding. ‘Burggraaffs werk bevindt zich op een uniek snijvlak van data science, biochemie en voedingswetenschappen,’…

Op 5, 6 en 7 oktober 2015 wordt bekend wie de Nobelprijzen krijgen voor fysiologie/geneeskunde, natuurkunde en chemie. Wat betekenen de ontdekkingen van de winnaar voor toekomstig onderzoek en voor de maatschappij? Wat voor onderzoek wordt in Leiden gedaan op het betreffende gebied? Leidse wetenschappers…

Ziekenhuisbacteriën die ongevoelig zijn voor antibiotica vormen een groeiend probleem. De Leidse antibiotica-expert Gilles van Wezel gaat samen met collega Michael Richardson en met experts van het LUMC en Naturalis op zoek naar nieuwe antibiotica in het gif van slangen en schorpioenen. Daarvoor krijgt…

Promotie

Promotie

Promotie

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Het Natuurwetenschappelijk Gezelschap Leiden heeft haar succes mede te danken aan de diverse besturen die de lezingen, vergaderingen en activiteiten van het gezelschap hebben verzorgd.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Promotor: Prof.dr. H.S. Overkleeft

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Promotor: A.P. IJzerman

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: A.P. IJzerman

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Leiden en Delft zijn zeer geschikt om de MST te combineren met persoonlijke ontwikkeling en te werken aan jouw toekomst.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

Gilles van Wezel was vrijdag 6 April te zien in De Buitendienst waar hij werd betrokken in een aflevering over giftige medicijnen.