This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Het programma ‘uNMR-NL’, een project om een 1.2 GHz NMR spectrometer in Nederland te plaatsen voor chemisch onderzoek, heeft 18,5 miljoen euro ontvangen om deze grootschalige faciliteit op te zetten. Dit wordt vanmiddag in Utrecht bekend gemaakt door staatssecretaris Zijlstra van OCW en Jos Engelen,…

Dr. Bela Bode ontvangt van de Alexander von Humboldt-stichting de Feodor Lynen onderzoeksbeurs voor de ontwikkeling van nieuwe methoden voor verbetering van het signaal in de vaste stof NMR. Hij streeft naar een specifiek analytisch instrument voor oppervlakte-studies en onderzoek over membranen en…

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Onderzoek aan het Leids Instituut voor Onderzoek in de Natuurkunde (LION) is fundamenteel en nieuwsgierigheids-gedreven. Al onze wetenschappers delen de wens om de kennis van de wereld om ons heen te vermeerderen, in een open, nieuwsgierige sfeer, waarin innovatieve ideeën ontstaan die toepassingen…

Nico Schrijver emeritus hoogleraar Internationaal Publiekrecht en staatsraad bij de Raad van State is door de Europese Unie en het Verenigd Koninkrijk benoemd als lid van het arbitragepanel dat bevoegd is om geschillen te beslechten over het terugtrekkingsakkoord EU-VK.

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: Roeland M.H. Merks

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

The applications of studying the early development of insects range from agriculture to material science.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotores: A.H. Meijer, H.P. Spaink

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Promotor: J. Kuiper

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

Studies naar perceptuele besluitvorming presenteren dezelfde stimulus doorgaans herhaaldelijk tijdens een experimentele sessie, maar negeren de volgorde van deze observaties, waarbij wordt uitgegaan van een onrealistische stabiliteit van beslissingsstrategieën tijdens proeven. Maar zelfs ‘stabiel’,…

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Lezing

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…

'White supermacism' is een aanjager van verhalen over verkiezingsfraude, betoogt universitair docent Sara Polak in Het Financieele Dagblad.

Studievoorlichting

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska