950 zoekresultaten voor “synthesis he molecular” in de Publieke website
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Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Tales of Orion: the interplay of gas, dust, and stars in the interstellar medium
Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Deciphering the atomic structure of the electrified metal oxide-electrolyte interface
Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Potential interference of fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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Anthe Janssen wint Unilever Research Prijs 2014
Anthe Janssen studeerde ‘summa cum laude’ af voor de masteropleiding Chemistry. Hij gebruikte NMR methoden om inzicht te krijgen in de synthese en het gedrag van bio suiker.
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Energy & Sustainability
Naar schatting bestaat de wereldbevolking over twintig jaar uit ongeveer 8,7 miljard mensen, terwijl dat aantal nu 7,3 miljard is. Deze groei, gecombineerd met de bijbehorende groei in consumptie en de verbeteringen in levensstandaarden, zal resulteren in een enorme groei in de vraag naar voedsel, verbruiksgoederen,…
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MAGL modulators: structure-guided optimisation and characterisation
The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.
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Chemical Biology
Het chemische biologie-onderzoek bij het Leids Instituut voor Chemisch Onderzoek (LIC) is gericht op het begrijpen van biologische processen op moleculair niveau, om zo onze kennis te vergroten over gezondheid en ziekte van de mens.
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Olivier BéquignonFaculteit der Wiskunde en Natuurwetenschappen
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Toelating en Aanmelding
Is MST de studie die bij je past? Dan kun je je inschrijvenaan de hand van onderstaand stappenplan. Je schrijft je in bij de Universiteit Leiden. De Universiteit Leiden zorgt voor je inschrijving bij de TU Delft.
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Richard van den BergFaculteit der Wiskunde en Natuurwetenschappen
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Stan van BoeckelFaculteit der Wiskunde en Natuurwetenschappen
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Gijs van der MarelFaculteit der Wiskunde en Natuurwetenschappen
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Mark OverhandFaculteit der Wiskunde en Natuurwetenschappen
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Dmitri FilippovFaculteit der Wiskunde en Natuurwetenschappen
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Poprhyrin-based metal-organic frameworks for the electrochemical oxygen reduction reaction
Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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NMR Faciliteit
Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Morphogenesis and protein production in Aspergillus niger
Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.
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Universiteitscampus Spui feestelijk geopend: ‘Vandaag barst het los’
Via een gouden loper wandelden maandag 2 februari studenten, medewerkers en nieuwsgierige Hagenaars voor het eerst Universiteitscampus Spui binnen.
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Alan Kai HassenFaculteit der Wiskunde en Natuurwetenschappen
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Freek Janssen wint KNCV Farmacochemie prijs voor beste presentatie
Freek Janssen kreeg tijdens de FIGON Dutch Medicine Days 2015 op 5 oktober in Ede de KNCV Farmacochemie prijs voor beste presentatie uitgereikt. Janssen ontvangt deze prijs voor zijn presentatie
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Wetenschap vertalen in behandelingen voor zeldzame metabole ziekten
De Leidse biotech-startup Azafaros heeft met succes een financieringsronde afgerond waarin 25 miljoen euro aan investeringen zijn toegezegd voor het ontwikkelen van behandelingen van zeldzame metabole aandoeningen. Het bedrijf heeft een exclusieve licentie voor een reeks nieuwe gepatenteerde verbindingen,…
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Two-Prover Bit-Commitments: Classical, Quantum and Non-Signaling
This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.
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Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu
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Benodigde documenten
Om je aan te melden voor de bacheloropleiding Molecular Science and Technology heb je meerdere documenten nodig. Zorg ervoor dat je deze documenten bij de hand hebt.
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Clinical and molecular insights into BAFopathies
Promotie
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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Unveiling the third dimension: vertical structure as a probe of planet formation conditions
Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…
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Disentangling a complex genus: systematics, biogeography and bioactivity of the genus Phyllanthus L. and related genera of tribe Phyllantheae
The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…