In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Investigating domestic crafts and subsistence activities through experiments and material analysis

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

The master’s specialisation Evolutionary Biology at Leiden University investigates biology at all levels. The specialisation includes genomics, functional developmental genetics, paleobiology, behavioral biology and evolutionary ecology.

Do you have any questions about the master’s programme Research in Biological- and Soft-Matter Physics? Please contact us.

Find out how to apply for Research in Physics, Biological and Soft Matter Physics at Leiden University by following our step-by-step guide.

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Rembrandt Year is concluding with a major exhibition at Museum De Lakenhal. There are still numerous other activities such as lectures, the University Rembrandt Route and the screening of a critical documentary.

The Biological- and Soft-Matter Physics Master specialisation is one of the two programmes Leiden offers in experimental Physics. The programme can to a high degree be tailored to individual needs and interests.

Research at the SBC group is comprised of the following research themes:

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Promotor: Prof.dr. J.N. Kok

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

The research in Biological- and Soft-Matter Physics specialisation consists of 120 European Credit Transfer System (EC) points and includes electives (60 EC) and two research projects (60 EC).

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.

Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

Lecture

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the track-specific courses, the elective courses, a research internship and a thesis.

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Are you interested in the neurocognitive and biological roots of learning, behaviour and emotions in children? If so, the programme in Applied Neuroscience in Human Development might be the specialisation you are looking for.

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Where did species survive the cold cycles of the current Ice Age?

Professor at the Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria - South Africa

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Supervisor: Gerard van Westen

School of pharmaceutical sciences, University of Geneva - Switzerland

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The Biological- and Soft-Matter Physics specialisation is an excellent preparation for pursuing a PhD degree in physics.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.