1,534 search results for “clinical metals” in the Public website
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Quantum dynamics of H2 on metal surfaces: researching the role of surface atoms
This research focuses on the (Quantum) Dynamics (QD) of the reactive scattering of H2 from metal surfaces.
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Online Course Clinical Research Regulation in the Netherlands
Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…
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FAQ clinical specialisations of the Master in Psychology
Below you will find the answers to some of the frequently asked questions about admission to the clinical specialisations of the Master in Psychology.
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FAQ clinical specialisations of the Master in Psychology
Below you will find the answers to some of the frequently asked questions about admission to the clinical specialisations of the Master in Psychology.
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FAQ clinical specialisations of the Master in Psychology
Below you will find the answers to some of the frequently asked questions about admission to the clinical specialisations of the Master in Psychology.
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FAQ clinical specialisations of the Master in Psychology
Here you will find the answers to some of the frequently asked questions about admission to the clinical specialisations of the Master in Psychology.
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FAQ clinical specialisations of the Master in Psychology
Below you will find the answers to some of the frequently asked questions about admission to the clinical specialisations of the Master in Psychology.
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Metals in the diffuse gas around high-redshift galaxies
Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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Online Course Clinical Kidney, Pancreas and Islet Transplantation
Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Buddhist and Hindu Metal Images of Indonesia: Evidence for shared artistic and religious networks across Asia (c.6th-10th century)
Mathilde Mechling defended her thesis on 28 january 2020.
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Mapping for meaning: using concept maps to integrate clinical and basic sciences in medical education
In which way and to which extent is integration articulated in concept maps and which factors affect the resulting concept maps? By which factors is the perceived usefulness of such concept maps affected?
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Course Anatomy of the Abdomen and the Pelvis: A Journey from Basic to Clinic
In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.
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From labelled to the optimal clinical dose: Model-informed dose optimization in medical oncology practice
In this PhD thesis, available data on the PK and/or PD of different targeted therapies, chemotherapy and immunotherapies obtained during both routine clinical practice and prospective clinical studies were analyzed.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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energy transition: analyzing flows and stocks of critical and other metals
The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Green miner: new plant species mines metal
A plant that takes metal from the ground all by itself: a natural way to mine or to clean the soil. PhD student Roderick Bouman (Hortus Botanicus Leiden) described a new plant species from Sabah, Borneo, which can be used to extract nickel. In an open access article in Botanical studies, he and the…
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Going accurate for molecule – metal surface interactions
Researchers from the THEOR CHEM group at Leiden University strive to set new benchmarks in the accuracy of the prediction of interaction energies between molecules and metal surfaces.
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Clearing the haze: investigating the clinical pharmacology of cannabinoids
PhD defence
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Final presentations Area Study Sustainability: Wheels of Metals
Friday 30 January 2015 were the final presentations of the last course of the Minor Sustainable Development.
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How two metal detectorists discovered a complete Roman treasure
In 2017, in an ordinary field, two brothers from Brabant discovered more than 100 ancient coins. The Leiden historian who examined the coins concluded that they constituted a genuine Roman treasure. Here follows a reconstruction in three acts.
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Jingjing Cao -
Applications of AdS/CFT to strongly correlated matter: from numerics to experiments
What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…
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Through the magnifying glass
Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.
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Improving painkiller dosing in the clinic
Children, cardiac surgery patients or people who are obese. How can we improve the dosing of painkillers for these patients? Hospital pharmacist Sjoerd de Hoogd of the St. Antonius Hospital in Utrecht investigated this. He combined data from the hospital with the knowledge and expertise of the Leiden…
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IHL Clinic Exchange Conference
The Kalshoven-Gieskes Forum is proud to announce that we will host the second annual “IHL Clinic Exchange Conference”, from 8 to 14 December, in The Hague.
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Luminescence and applications of lanthanoid coordination polymers
Promotor: E. Bouwman, Co-Promotor: S. Bonnet
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Martina Vijver -
A three-step approach to supporting patient self-management in clinical practice
The aim of this project is to develop, evaluate, and multicentre implement a blended form of cardiac rehabilitation that uses a theory-based approach to guide patients to full self-management.
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Do common antibiotic treatments influence emotional processing?
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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MOOC on Clinical Kidney Transplantation
Kidney transplantation used to be an experimental risky procedure, but is now routinely performed by many countries worldwide.
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Manja KoendersFaculty of Social and Behavioural Sciences
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TV-Interview Rene Kleijn about metals scarcity in relation to the energy transition
CML-researcher Rene Kleijn has spoken about metals scarcity in relation to the energy transition in a new Dutch popular scientific TV show called
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semi-local DFT is accurate for dissociative chemisorption on a transition metal surface, and when it is not
Density functional theory (DFT) with so-called semi-local exchange has been remarkable accurate for some dissociative chemisorption reactions on metals, but it has notoriously failed for others. A team of researchers from the University of California at Irvine and the Leiden Institute of Chemistry have…
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Non-invasive biomarkers for inflammatory skin diseases: towards systems dermatology
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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predictor for variation with geometry of barriers for reactions on metals
A semi-empirical version of the specific reaction parameter approach to density functional theory (SRP-DFT) has been remarkably successful at predicting dissociative chemisorption probability vs. incidence energy curves for reactions on metal surfaces. New quantum Monte Carlo (QMC) calculations on the…
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Observing what cannot be observed: computational electrochemistry from carbon to hydrogen
In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.
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Copper complexes for bioinspired electrocatalysis relevant to the reduction of oxygen
This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.
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Johanna Greeven
Faculty of Social and Behavioural Sciences
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Dutch fertility clinic faces legal consequences over false information
The largest fertility clinic in the Netherlands lied to women, sperm donors, and the Health and Youth Care Inspectorate. On ‘Nieuwsuur’, Mirjam Sombroek van Doorm, Professor of Law and Health, foresees legal consequences: 'The situation is too serious.'
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Material demand for key infrastructures in emerging energy and digital technologies under the low-carbon transition: estimation and sustainability
The global transition toward low-carbon energy systems and the rapid expansion of digital technologies, including artificial intelligence, are reshaping how modern societies produce, move, and process energy and information.
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Cathodic corrosion
Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.
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Healthcare Information System Engineering: AI Technologies and Open Source Approaches
Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.